Homology between surface protein antigen genes of Streptococcus sobrinus and Streptococcus mutans

Takahashi, I.; Okahashi, N.; Sasakawa, C.; Yoshikawa, M.; Hamada, S.; Koga, T.

Febs Letters 249(2): 383-388


ISSN/ISBN: 0014-5793
PMID: 2661267
DOI: 10.1016/0014-5793(89)80664-7
Accession: 031717414

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The structural gene (pag gene) for a 210 kDa protein antigen of Streptococcus sobrinus serotype g was cloned and compared with that (pac gene) of a 190 kDa protein antigen of Streptococcus mutans serotype c. Immunodiffusion analysis revealed that the product of the pag gene immunologically cross-reacted with that of the pac gene. Southern blot and nucleotide sequence analyses revealed that a significant homology existed between the middle regions of the two structural genes.