+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

How to run a brain bank: potentials and pitfalls in the use of human post-mortem brain material in research



How to run a brain bank: potentials and pitfalls in the use of human post-mortem brain material in research



Journal of Neural Transmission. Supplementum 39: 235-243



Brain banks for neurological diseases serve as a link between the clinician, the neuropathologist and the basic scientist who require brain tissue samples from patients who have undergone a thorough clinical investigation and whose brains have been subjected to detailed neuropathological analysis. In order to provide research groups with post-mortem brain tissue from patients who show clinical signs of dementia such as Alzheimer's disease (AD), senile dementia of Alzheimer type (SDAT), vascular dementia including multi-infarct dementia (MID) and mixed dementia, a brain bank was established at Huddinge University Hospital at the end of 1988. The brain bank provides either rapidly or slowly frozen tissue samples, tissue samples fixed in formalin (short/long fixation time), cerebrospinal fluid (CSF), and blood samples. Average postmortem times are from 3-47 hours. The information available on the cases includes the clinical diagnosis, the premortem clinical investigation with behavioral observations, psychometric and neuropsychological test data, premortem medication, cause of death, agonal state, pH in brain and CSF, and the general anatomic and neuropathologic assessments leading to the final diagnosis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 031729568

Download citation: RISBibTeXText

PMID: 8360663


Related references

Pitfalls in membrane binding sites studies in post-mortem human brain. Journal of Receptor Research 7(1-4): 527-554, 1987

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables. Acta Neuropathologica Communications 5(1): 16, 2017

Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease. Neuroscience 69(1): 125-138, 1995

Post mortem stability of somatostatin like immuno reactivity in mouse brain under conditions simulating handling of human autopsy material. Neurochemical Research 6(7): 787-791, 1981

The workflow from post-mortem human brain sampling to cell microdissection: a Brain Net Europe study. Journal of Neural Transmission 122(7): 975-991, 2015

Post-mortem stability of dopamine, glutamate decarboxylase and choline acetyltransferase in the mouse brain under conditions simulating the handling of human autopsy material. Journal of Neurochemistry 31(1): 381-383, 1978

Mono amine neuron systems in the normal and schizophrenic human brain fluorescence histochemistry of fetal neuro surgical and post mortem material. Usdin, Earl And Solomon H Snyder (Ed ) Frontiers in Catecholamine Research: Proceedings Of The Third International Catecholamine Symposium Strasbourg, France, May 20-25, Xvi+1219p Illus Pergamon Press, Inc : New York, N Y , U S A ; London, England (1974), 1973

Post mortem stability of dopamine glutamate decarboxylase ec 4.1.1.15 and choline acetyl transferase ec 2.3.1.6 in the mouse brain under condition simulating the handling of human autopsy material. Journal of Neurochemistry 31(1): 381-384, 1978

Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells. Journal of Medical Microbiology 53(Pt 10): 1007-1012, 2004

Post Mortem Changes in the Brain. a Contribution to the Problem of Brain Swelling and Brain Edema. Deutsche Zeitschrift für die Gesamte Gerichtliche Medizin 54: 178-191, 1963

The Post-Mortem Brain in Psychiatric Research. European Journal of Neurology 10(2): 193-193, 2003

Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: a proposed protocol. Bmc Research Notes 7: 370, 2014

Transmitters and related substances in brain material: an index of terminal and/or post-mortem biochemical change. Lancet 1(8056): 156-157, 1978

A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques 59(4): 241, 2015

Guanidino compound levels in blood, cerebrospinal fluid, and post-mortem brain material of patients with argininemia. Molecular Genetics and Metabolism 100(Suppl. 1): S31-S36, 2010