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Identification of a liver nuclear protein factor responsive to the repression of cholesterol 7-alpha-hydroxylase gene by bile acids


Identification of a liver nuclear protein factor responsive to the repression of cholesterol 7-alpha-hydroxylase gene by bile acids



FASEB Journal 8(4-5): A543



ISSN/ISBN: 0892-6638


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(PDF emailed within 1 workday: $29.90)

Accession: 031779446

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Related references

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. Journal of Biological Chemistry 276(33): 30708-30716, 2001

The feedback repression of cholesterol 7-alpha-hydroxylase by bile acids is mediated through protein kinase C. Gastroenterology 108(4 Suppl): A1177, 1995

Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids. Journal of Lipid Research 42(9): 1402-1412, 2001

The negative effects of bile acids and tumor necrosis factor-a on the transcription of cholesterol 7a-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. The Journal of Biological Chemistry 276(33): 708-16, 2001

Repression of cholesterol 7 alpha-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes. Journal of Lipid Research 36(6): 1359-1369, 1995

Protein kinase C activation/cellular redistribution and cholesterol 7-alpha-hydroxylase mRNA repression by bile acids in rat hepatocytes. Hepatology 22(4 Part 2): 239A, 1995

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Hepatocyte nuclear factor 4 binds the bile acid response element II of the rat cholesterol 7 alpha-hydroxylase gene. FASEB Journal 12(8): A1390, 1998

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The bile acid repression of cholesterol 7-alpha-hydroxylase gene transcription may be mediated through multiple elements in the promoter. Protein Engineering 8(Suppl ): 76, 1995

Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells. Hepatology 43(6): 1202-1210, 2006

Rat hepatoma L35 cells, a liver-differentiated cell line, display resistance to bile acid repression of cholesterol 7 alpha-hydroxylase. Journal of Lipid Research 37(3): 588-598, 1996

The bile acid responsive element is located in the proximal promoter of the cholesterol 7-alpha-hydroxylase gene. FASEB Journal 8(7): A1250, 1994