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Identification of radiolabeled metabolites of nicotine in rat bile Synthesis of S- -nicotine N-glucuronide and direct separation of nicotine-derived conjugates using high-performance liquid chromatography



Identification of radiolabeled metabolites of nicotine in rat bile Synthesis of S- -nicotine N-glucuronide and direct separation of nicotine-derived conjugates using high-performance liquid chromatography



Journal of Chromatography Biomedical Applications 621(1): 49-53



Four metabolites of nicotine, including two glucuronides, have been separated by high-performance liquid chromatography. This separation was applied to identification of biliary metabolites of radiolabeled nicotine by radiometric detection. S-(-)-Nicotine N-glucuronide was synthesized and used as a standard in method development.

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Accession: 031789479

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PMID: 8308087


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