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Intramolecular 1,6-conjugate addition approach for construction of the hydrindane framework Total synthesis of -coronafacic acid



Intramolecular 1,6-conjugate addition approach for construction of the hydrindane framework Total synthesis of -coronafacic acid



Tetrahedron Letters 37(37): 6745-6748



A new approach for the construction of the hydrindane framework has been achieved by intramolecular 1, 6-conjugate addition under some basic conditions. The precursors, , , , -unsaturated esters (11a-11d) were synthesized from the ester 8 and acrolein derivatives (6a-6d) via aldol condensation. This methodology was applied to the total synthesis of (±)-coronafacic acid and its analogues.

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Accession: 032016186

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DOI: 10.1016/s0040-4039(96)01457-8


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