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Chapter 32,032

Investigation of genetic markers in patients with Crohn's disease and ulcerative colitis

Purrmann, J.; Bertrams, J.; Knapp, M.; Cleveland, S.; Gemsa, R.; Hengels, K.J.; Strohmeyer, G.

Zeitschrift für Gastroenterologie 27(7): 366-369

1989


ISSN/ISBN: 0044-2771
PMID: 2528241
Accession: 032031991

Inflammatory bowel diseases (IBD) as Crohn's disease (CD) and ulcerative colitis (UC) are believed to have a genetic basis. Additional factors are supposed to promote the development of IBD. However, apart from a few reports of HLA associations which await confirmation by other groups strong associations to (a) particular genetic marker(s) are still lacking. We here report on previously unobserved associations of CD to MNSS and UC to the immunoglobulin heavy chain allotype Gm 1,-2,10. We suggest that these factors play a role in a wider spectrum of genetic markers for the development of IBD.

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