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Lipid products of PI 3-kinase regulate activity of ATP-dependent transporters in rat canalicular membrane vesicles






Hepatology 28(4 PART 2): 506A

Lipid products of PI 3-kinase regulate activity of ATP-dependent transporters in rat canalicular membrane vesicles



Accession: 032163016



Related references

Misra, S.; Ujházy, P.; Varticovski, L.; Arias, I.M., 1999: Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles. Bile acid transport and secretion in hepatocytes require phosphatidylinositol (PI) 3-kinase-dependent recruitment of ATP-dependent transporters to the bile canalicular membrane and are accompanied by increased canalicular PI 3-kinase activity. We...

Misra, S.; Ujhazy, P.; Varticovski, L.; Arias, I.M., 1999: Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles. Bile acid transport and secretion in hepatocytes require phosphatidylinositol (PI) 3-kinase-dependent recruitment of ATP-dependent transporters to the bile canalicular membrane and are accompanied by increased canalicular PI 3-kinase activity. We...

Sinicrope F.A.; Dudeja P.K.; Safa A.R.; Brasitus T.A., 1992: Modulation of p glycoprotein dependent drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles. Gastroenterology 102(4 PART 2): A398

Ujhazy, P.; Ortiz, D.F.; Misra, S.; Li, S.; Arias, I.M., 1999: ATP-dependent aminophospholipid translocase activity in rat canalicular membrane vesicles and its relationship to FIC1. Hepatology 30(4 PART 2): 462A

Kurumi Y., 1991: Membrane fluidity and membrane lipid composition in rat liver sinusoidal and canalicular membrane vesicles. Membrane fluidity and phospholipid composition of sinusoidal membrane vesicles {SMV} and canalicular membrane vesicles {CMV} of rat hepatocytes were studied to investigate their relevance to the topological difference in membrane function. Membran...

Nishida, T.; Arias, I.M., 1992: Evidence for a single ATP-dependent and membrane potential-dependent bile acid transporter in rat canalicular membrane vesicles. Hepatology 16(4 PART 2): 149A

Ballatori, N.; Moseley, R.H.; Boyer, J.L., 1986: Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles. The driving forces for L-glutamate transport were determined in purified canalicular (cLPM) and basolateral (i.e. sinusoidal and lateral; blLPM) rat liver plasma membrane vesicles. Initial rates of L-glutamate uptake in cLPM vesicles were stimulat...

Nishida T.; Hardenbrook C.; Gatmaitan Z.; Arias I.M., 1990: Synergistic atp dependent and potential dependent transport of bsp by rat canalicular membrane vesicles. Hepatology 12(4 PART 2): 892

Shilling, A.D.; Azam, F.; Kao, J.; Leung, L., 2005: Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. Introduction: A novel application of a Ultrafree filter cartridge/centrifugation method was evaluated to determine uptake in canalicular membrane vesicles (CMVs) from SD rats, beagle dogs, cynomolgus monkeys (common safety species in the pharmaceu...

Buechler, M.; Boehme, M.; Ortlepp, H.; Keppler, D., 1994: Functional reconstitution of ATP-dependent transporters from the solubilized hepatocyte canalicular membrane. The hepatocyte canalicular membrane contains several primary-active ATP-dependent export carriers including one for bile salts and one for leukotriene C4 and related conjugates. The molecular identity of both transporters has not been fully elucid...