EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Losartan inhibits sympathetic and cardiovascular responses to carotid occlusion


, : Losartan inhibits sympathetic and cardiovascular responses to carotid occlusion. Hypertension 23(6 Pt 2): 827-831

We have reported that inhibition of angiotensin-converting enzyme with captopril attenuates the cardiovascular responses to bilateral carotid occlusion in conscious rabbits and proposed that the attenuation results from removal of a facilitatory action of angiotensin II on the sympathetic nervous system. The aim of the present study was to assess the effect of carotid occlusion on renal sympathetic nerve activity in conscious rabbits and to investigate the effect of the angiotensin II subtype 1 (AT-1) receptor antagonist losartan on the cardiovascular and renal sympathetic nerve activity responses to carotid occlusion. In seven conscious, aortic depressor nerve-sectioned rabbits, carotid occlusion elicited prompt and reproducible increases in mean arterial pressure from 75+-2 to 124+-5 mmHg (P lt .001), heart rate from 285+-8 to 317+-9 beats per minute (P lt .01), and renal sympathetic nerve activity to 165+-11% of control (P lt .01). In the same rabbits, losartan (5 mg/kg IV) decreased mean arterial pressure by 9+-2 mm Hg (P lt .01), increased renal sympathetic nerve activity to 143+-13% of control (P lt .05), but did not alter heart rate. Losartan significantly attenuated (P lt .01) the mean arterial pressure (66+-2 to 81+-2 mm Hg), heart rate (282+-9 to 289+-7 beats per minute), and renal sympathetic nerve activity (143+-13% to 159+-15% of control) responses to carotid occlusion. The responses to carotid occlusion were not restored when the hypotension produced by losartan was reversed by phenylephrine infusion, and nitroprusside-induced hypotension did not attenuate the pressor or renal sympathetic nerve activity responses to carotid occlusion. These results provide evidence that endogenous angiotensin II facilitates the cardiovascular and sympathetic nerve activity responses to carotid occlusion by an action on central AT-1 receptors.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 032198308

PMID: 8206612

DOI: 10.1161/01.HYP.23.6.827

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Edward A. Boyden, 1932: Congenital absence of the kidney An interpretation based on a 10-mm human embryo exhibiting unilateral renal agenesis. The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 52(4): 325-349

Erwin, Meridith E.; Jones, Ronald N., 1993: Roxithromycin in vitro susceptibility testing of Haemophilus influenzae by NCCLS methods. Journal of Antimicrobial Chemotherapy 32(4): 652-654

Christaki, T.; Tzia, C., 2002: Quality and safety assurance in winemaking. Winemaking poses many quality (appearance, taste, consumer acceptability) and safety (chemicals, metal parts) hazards. In this work, an effort is made for quality and safety analysis of winemaking, by describing and outlining the incoming hazards...

Okuyama T.; Nagamatsu H.; Kitano M.; Fueno T., 1986: Nucleophilic catalysis of hydrolysis of a schiff base by amines intramolecular catalysis of transimination. Certain groups of amines were found to catalyze hydrolysis of N-(o-methoxybenzylidene)-2-methoxyethylamine through transimination. The rate-determining transimination was followed by rapid hydrolysis of an intermediate Schiff base. Rate constants...

Ala, A. Ya, 1989: Laws of inheritance of characters in interspecific soya hybrids. This is an English language translation of a paper abstracted previously from the original Russian source. It concerns the inheritance of testa, plant hair and corolla colour in Glycine max X G. soja crosses.

MacDonald W., 1976: Cretaceous-Tertiary evolution of the Caribbean. Transactions of the Caribbean Geological Conference = Memorias - Conferencia Geologica del Caribe 7): 69-78

Richards A.L.; Okuno T.; Takagaki Y.; Djeu J.Y., 1988: Natural cytotoxic cell specific cytotoxic factor produced by il 3 dependent basophilic mast cells relationship to tnf. The murine IL-3-dependent mast cell line, PT18-A17, and the rat basophilic leukemia cell line, RBL-2H3, were found to mediate natural cytotoxic (NC) activity via the release of a soluble factor which specifically lysed NC-sensitive WEHI-164 but no...

Kidundo, M., 1997: Melia volkensii - propagating the tree of knowledge. The use of Melia volkensii as part of an indigenous agroforestry system is already widespread in the semiarid areas of eastern and central Kenya. Farmers speak of the importance of this tree in income generation to help them cover the costs of the...

Burton, R. A.; Qi ZeWen; Roulin, S.; Fincher, G. B., 1998: Gene structure and a possible cytoplasmic location for (1 <- 3)- beta -glucanase isoenzyme GI from barley (Hordeum vulgare). A genomic DNA fragment encoding (1<-3)- beta -glucan endohydrolase isoenzyme GI [glucan endo-1,3- beta -d-glucosidase] from barley has been isolated and characterized (EMBL/GenBank/DDBJ accession number AF055328). The gene has clearly identifia...

Floeter M.K.; Sholomenko G.N.; Burke R.E., 1991: Short latency epsps in lumbosacral motoneurons produced by stimulation in the medial longitudinal fasciculus. Society for Neuroscience Abstracts 17(1-2): 646