+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Melanoma growth stimulatory activity in primary malignant melanoma: prognostic significance

Melanoma growth stimulatory activity in primary malignant melanoma: prognostic significance

Modern Pathology 15(5): 532-537

Malignant melanoma (MM) cells do not require all exogenous growth factors of normal melanocytes. It is hypothesized that they make their own growth factors including melanoma growth stimulatory activity (MGSA). Cultured melanoma cells respond to MGSA with increased growth and angiogenesis suggesting a role for MGSA in MM proliferation, differentiation, and progression. We assessed the prognostic significance of MGSA expression in 37 primary MM immunostained for MGSA. Immunostains were graded for intensity (0-3+), percentage of cells immunostained, and location of immunostain (intraepidermal, junctional, or dermal). In addition, 31 melanocytic and 23 dysplastic nevi were similarly studied for MGSA expression. All MM showed the presence of immunostain, 6 (16%) 1+, 12 (32%) 2+, and 19 (51%) 3+. Six (16%) had immunostain in < or = 50% tumor cells, 31 (84%) in >50%. A significant number of MM showed >50% tumor cells staining at the dermal-epidermal junction compared with intraepidermal staining (P <.0001). Intensity and amount of immunostain did not correlate with Clark's or Breslow's level. During a mean follow-up of 60 months (range: 5-101) on 27 patients, there were 4 local recurrences, 6 distant metastases, and 10 deaths. MGSA expression was not of prognostic significance with regard to survival (overall, disease free), or local recurrence or distant metastasis in primary MM. MGSA expression was similar in benign melanocytic and dysplastic nevi. Strong diffuse expression was noted in the junctional component of all junctional and most compound nevi. The dermal component consistently expressed less or no (in 45% of intradermal nevi) MGSA. MGSA expression does not correlate with prognosis in MM. Increased expression of MGSA at the dermal-epidermal junction in nevi and MM may indicate a role for MGSA in early local growth, before development of atypia.

Accession: 032294198

Download citation: RISBibTeXText

PMID: 12011258

DOI: 10.1038/modpathol.3880559

Related references

Growth factor modulation of melanoma growth stimulatory activity mRNA expression in human malignant melanoma cells correlates with cell growth. Journal of Cellular Biochemistry 39(4): 421-428, 1989

Prognostic significance of melanoma inhibiting activity levels in malignant melanoma. Melanoma Research 11(6): 627-632, 2001

Preparation of a monoclonal antibody to a melanoma growth-stimulatory activity released into serum-free culture medium by Hs0294 malignant melanoma cells. Journal of Cellular Biochemistry 34(3): 169-185, 1987

The role of melanoma growth-stimulatory activity in melanoma tumorigenesis and angiogenesis. Rollins, B J Contemporary Cancer Research; Chemokines and cancer 169-189, 1999

The distribution of immunoreactive melanoma growth stimulatory activity mgsa is not restricted to melanoma tissue. Journal of Cellular Biochemistry Supplement (11 PART A): 38, 1987

Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution. Journal of Cellular Biochemistry 36(2): 185-198, 1988

Prognostic significance of nestin in primary malignant melanoma of the oral cavity. Melanoma Research 26(5): 457-463, 2018

Tissue factor has no prognostic significance in primary cutaneous malignant melanoma. Melanoma Research 7(SUPPL 1): S132, 1997

Prognostic significance of proliferation and motility in primary malignant melanoma of the skin. Journal of Cutaneous Pathology 19(2): 110-115, 1992

Release of an auto stimulatory growth activity by human malignant melanoma cells. Sato, G H , A B Pardee And D A Sirbasku (Ed ) Cold Spring Harbor Conferences on Cell Proliferation, Vol 9 Growth Of Cells in Hormonally Defined Media, Part A And B Xxxi+624p (Part A); Xvii+586p (Part B) Cold Spring Harbor Laboratory: Cold Spring Harbor, N Y , Usa Illus P885-898, 1982

Extraction of a melanoma growth-stimulatory activity from culture medium conditioned by the Hs0294 human melanoma cell line. Cancer Research 43(5): 2106-2112, 1983

Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. Archiv für Dermatologische Forschung 252(3): 193-201, 1975

Tyrosinase activity in three types of the malignant melanoma: Superficial spreading melanoma, mentigo maligna melanoma and Nodular Melanoma. Archives of Dermatological Research 252(3): 193-201, 1975

Melanoma Inhibiting Activity A new prognostic serum marker in patients with malignant melanoma. Clinical Chemistry & Laboratory Medicine 37(SPEC SUPPL ): S226, 1999

Prognostic value of melanoma inhibitory activity protein in localized cutaneous malignant melanoma. Journal of Skin Cancer 2014: 843214, 2014