+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neutral and anionic cyclodextrins in capillary zone electrophoresis: enantiomeric separation of ephedrine and related compounds



Neutral and anionic cyclodextrins in capillary zone electrophoresis: enantiomeric separation of ephedrine and related compounds



Electrophoresis 15(6): 799-803



Two methods for the enantiomeric separation of chiral ephedrine alkaloids (ephedrine, methylephedrine, methylpseudoephedrine and norephedrine) by capillary zone electrophoresis in uncoated capillaries were developed. Both methods were optimized to more than 100 000 theoretical plate numbers. The first method used a neutral cyclodextrin (CD) derivative: heptakis (2,6–di-O-methyl)-β-cyclodextrin at an acidic pH of 2.5 (20 mM phosphate buffer) at an 18 mM concentration. The second used a newly developed acidic CD derivative, the tetrakis[6-O-(4-sulfobutyl)]-β-cyclodextrin sodium salt. The benefits of this new reagent for the chiral separation are a wide range of basic pH available for the enantiomeric resolution. It is also useful for other cases, e.g. preventing adsorption without additives.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 032518722

Download citation: RISBibTeXText

PMID: 7982402

DOI: 10.1002/elps.11501501112


Related references

Optimization of enantiomeric separations for basic compounds in capillary zone electrophoresis using neutral and anionic cyclodextrins as chiral selectors. Biomedical Chromatography 9(6): 265-266, 1995

Characterization of sulfated beta-cyclodextrins and determination of enantiomeric purity of (1 R,2S)-ephedrine by capillary zone electrophoresis. Journal of Separation Science 27(13): 1102-1108, 2004

Enantiomeric separation of sulfonium ions by capillary electrophoresis using neutral and charged cyclodextrins. Analytical Chemistry 70(17): 3612-3618, 1998

Enantiomeric separation of antimalarial drugs by capillary electrophoresis using neutral and negatively charged cyclodextrins. Journal of Pharmaceutical and Biomedical Analysis 54(3): 475-481, 2011

Use of charged and neutral cyclodextrins in capillary zone electrophoresis Enantiomeric resolution of some 2-hydroxy acids. Journal of Chromatography 638(2): 247-253, 1993

Cyclodextrins as buffer additives for the enantiomeric separation of pinacidil in capillary zone electrophoresis. Journal of Chromatography A 749(1-2): 300-303, 1996

Enantiomeric separation of dansylamino acids by capillary zone electrophoresis based on complexation with cyclodextrins. Fresenius' Journal of Analytical Chemistry 343(12): 896-900, 1992

Separation of positional isomers and enantiomers using capillary zone electrophoresis with neutral and charged cyclodextrins. Journal of Chromatography A 652(1): 259-262, 1993

Determination of trace enantiomeric impurities in chiral compounds by capillary electrophoresis with uncoated, cationic, anionic and neutral surface modified capillaries. Journal of Chromatography A 817(1-2): 83-90,. 21, 1998

Enantiomeric separation of drugs with capillary electrophoresis with cyclodextrins. Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 156(6 Pt 2): 311-317, 2001

Enantiomeric separation of diltiazem, clentiazem, and its related compounds by capillary electrophoresis using polysaccharides. Journal of Chromatographic Science 33(12): 698-703, 1995

Use of 1H-NMR spectroscopy to determine the enantioselective mechanism of neutral and anionic cyclodextrins in capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis 15(9-10): 1603-1619, 1997

Enantiomeric separation of glycyl dipeptides by capillary electrophoresis with cyclodextrins as chiral selectors. Electrophoresis 20(17): 3417-3424, 1999

Enantiomeric separation of R,S-tolterodine and R,S-methoxytolterodine with negatively charged cyclodextrins by capillary electrophoresis. Journal of Separation Science 36(9-10): 1561-1567, 2013

Enantiomeric separation of 13 new amphetamine-like designer drugs by capillary electrophoresis, using modified-B-cyclodextrins. Chirality 25(10): 617-621, 2013