+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nonfatal demyelinating encephalomyelitis induced by coronavirus (JHM strain) infection in mice



Nonfatal demyelinating encephalomyelitis induced by coronavirus (JHM strain) infection in mice



Brazilian Journal of Medical and Biological Research 22(1): 77-80



C3H mice infected intravenously with the JHM strain of coronavirus showed high incidence of demyelination (44.8%) and low incidence of encephalitis-induced mortality (6.9%). High titers of virus were detectable in the brain and liver of mice only during the first 3 to 12 days of infection (10(3) and 10(4) PFU/g, respectively). Most of the animals recovered from the first phase of disease and some (11.1%) came down with paralysis 6 to 7 weeks after the infection, with no histological changes or virus detectable in their tissues.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 032565394

Download citation: RISBibTeXText

PMID: 2547471


Related references

Coronavirus JHM infection of rats as a model for virus induced demyelinating encephalomyelitis. Progress in Clinical and Biological Research 146: 13-22, 1984

Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection. Journal of Neuroimmunology 6(5): 325-336, 1984

The fate of oligodendroglia in coronavirus induced demyelinating encephalomyelitis. Periodicum Biologorum 96(3): 257, 1994

Immune regulation of coronavirus-induced demyelinating encephalomyelitis. Journal of Neurovirology 3(Suppl. 1): S56-S57, 1997

Coronavirus JHM-induced demyelinating encephalomyelitis in rats: influence of immunity on the course of disease. Progress in Brain Research 59: 221-231, 1983

Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis. Nature 305(5930): 150-153, 1983

Coronavirus-JHM-induced demyelinating encephalomyelitis in rats. Analysis of the intrathecal immune response. Annals of the new York Academy of Sciences 540: 663-664, 1988

Coronavirus jhm induced demyelinating encephalomyelitis in rats analysis of the intrathecal immune response. Journal of Neuroimmunology 16(1): 46-47, 1987

Patterns of oligodendrocyte pathology in coronavirus-induced subacute demyelinating encephalomyelitis in the Lewis rat. Glia 19(1): 1-12, 1997

Virological and immunological aspects of coronavirus induced subacute demyelinating encephalomyelitis in rats. Advances in Experimental Medicine and Biology 173: 259-270, 1984

Coronavirus induced demyelinating encephalomyelitis in rats: immunopathological aspects of viral persistency. Advances in Experimental Medicine and Biology 276: 637-645, 1990

Comparative analysis of coronavirus JHM-induced demyelinating encephalomyelitis in Lewis and Brown Norway rats. Laboratory Investigation; a Journal of Technical Methods and Pathology 57(4): 375-384, 1987

Characterization of CD4+T-cells infiltrating the central nervous system of rats with coronavirus JHM-induced demyelinating encephalomyelitis. Immunobiology 189(1-2): 221, 1993

Phenotypic and functional characterization of CD8+ T lymphocytes from the central nervous system of rats with coronavirus JHM induced demyelinating encephalomyelitis. Journal of Neurovirology 1(5-6): 340-348, 1995

Expression of interleukin mRNA in lymphocytes from the central nervous system of rats with coronavirus JHM induced demyelinating encephalomyelitis. Immunobiology 189(1-2): 215, 1993