+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Paranoid psychosis and myoclonus: flecainide toxicity in renal failure



Paranoid psychosis and myoclonus: flecainide toxicity in renal failure



Cardiology 111(2): 83-86



Flecainide is a sodium channel blocker used mainly in the treatment of supraventricular arrhythmias. Central nervous system side effects such as dizziness, visual disturbances, headache and nausea are commonly associated with flecainide, but severe central nervous system toxicity is rare. We report the first case of flecainide toxicity in a patient with end-stage renal failure. Cessation of flecainide therapy resulted in a fall in serum flecainide levels, with associated resolution of adverse central nervous system effects. We also review the pharmacokinetics of flecainide in patients with chronic kidney disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 032714571

Download citation: RISBibTeXText

PMID: 18376118

DOI: 10.1159/000119694


Related references

Paranoid psychosis due to flecainide toxicity in malignant neuropathic pain. Pain. 70(1): 93-94, 1997

Flecainide toxicity in renal failure. Proceedings 31(3): 328-330, 2018

Myoclonus in renal failure: Two cases of gabapentin toxicity. Epilepsy and Behavior Case Reports 2: 8, 2014

Late-onset paranoid psychosis as a distinct clinicopathologic entity: magnetic resonance imaging data in elderly patients with paranoid psychosis of late onset and schizophrenia of early onset. Neuropsychiatry Neuropsychology and Behavioral Neurology 12(4): 230-235, 1999

Conditioned blocking in patients with paranoid, non-paranoid psychosis or obsessive compulsive disorder: Associations with symptoms, personality and monoamine metabolism. Journal of Psychiatric Research 30(5): 369-390, 1996

Action myoclonus renal failure syndrome A unique cerebro-renal disorder. Neurology 60(5 Suppl. 1): A357, 2003

Situational analysis of a paranoid psychosis and the disappearance of the psychosis after the neurologic disease. Kitakanto Medical Journal 27(3): 191-197, 1977

Paranoid psychosis, epidermoid tumor, and epilepsy: "symptomatic" psychosis or coincidence?. Journal of Clinical Psychiatry 53(7): 257-258, 1992

When Paranoid Psychosis Becomes Dementia: Treatment of the Aging Patient with Chronic Psychosis. American Journal of Geriatric Psychiatry 26(3): S112-S113, 2018

Action myoclonus-renal failure syndrome: characterization of a unique cerebro-renal disorder. Brain 127(Pt 10): 2173-2182, 2004

Hemofiltration clearance of flecainide in a patient with acute renal failure. Intensive Care Medicine 14(3): 236-237, 1988

Pharmacokinetics of flecainide in patients with mild and moderate renal failure compared with patients with normal renal function. European Journal of Clinical Pharmacology 31(6): 711-714, 1987

Flecainide-induced myoclonus. Clinical Neuropharmacology 37(2): 65-66, 2015

Iatrogenic acute renal failure caused by overdosage of flecainide acetate. Presse Medicale 27(29): 1473-1475, 1998

Familial myoclonus-renal failure syndrome. Der Nervenarzt 72(8): 636-640, 2001