+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Pathogenesis of degenerative joint disease in the human temporomandibular joint



Pathogenesis of degenerative joint disease in the human temporomandibular joint



Critical Reviews in Oral Biology and Medicine 6(3): 248-277



The wide range of disease prevalences reported in epidemiological studies of temporomandibular degenerative joint disease reflects the fact that diagnoses are frequently guided by the presence or absence of non-specific signs and symptoms. Treatment is aimed at alleviating the disease symptoms rather than being guided by an understanding of the underlying disease processes. Much of our current understanding of disease processes in the temporomandibular joint is based on the study of other articular joints. Although it is likely that the molecular basis of pathogenesis is similar to that of other joints, additional study of the temporomandibular joint is required due to its unique structure and function. This review summarizes the unique structural and molecular features of the temporomandibular joint and the epidemiology of degenerative temporomandibular joint disease. As is discussed in this review, recent research has provided a better understanding of the molecular basis of degenerative joint disease processes, including insights into: the regulation of cytokine expression and activation, arachidonic acid metabolism, neural contributions to inflammation, mechanisms of extracellular matrix degradation, modulation of cell adhesion in inflammatory states, and the roles of free radicals and heat shock proteins in degenerative joint disease. Finally, the multiple cellular and molecular mechanisms involved in disease initiation and progression, along with factors that may modify the adaptive capacity of the joint, are presented as the basis for the rational design of new and more effective therapy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 032728863

Download citation: RISBibTeXText

PMID: 8785264

DOI: 10.1177/10454411950060030601


Related references

Pathogenesis of degenerative temporomandibular joint disease. Journal of Dental Research 72(ABSTR SPEC ISSUE): 344, 1993

Prevalence of degenerative joint disease of the temporomandibular joint: a systematic review. Clinical Oral Investigations 23(5): 2475-2488, 2019

Age-related changes in the temporomandibular joint of the senescence accelerated mouse. SAM-P/3 as a new murine model of degenerative joint disease. American Journal of Pathology 135(2): 379-385, 1989

The effects of temporomandibular joint internal derangement and degenerative joint disease on tomographic and arthrotomographic images. Oral Surgery Oral Medicine Oral Pathology 67(2): 220-223, 1989

Clinical comparative study of microcurrent electrical stimulation to mid-laser and placebo treatment in degenerative joint disease of the temporomandibular joint. Cranio 13(2): 116-120, 1995

The diagnosis and treatment of three chronic facial pain disorders: deafferentation neuralgia, degenerative joint disease of the temporomandibular joint, and myofascial syndrome. Journal of the Massachusetts Dental Society 35(4): 169-72 200-2, 1986

Solid-state temporomandibular joint imaging: accuracy in detecting osseous changes of degenerative joint disease and determining condylar spatial relations. American Journal of Orthodontics and Dentofacial Orthopedics 124(4): 452-457, 2003

Degenerative joint disease of the temporomandibular joint. Journal of Prosthetic Dentistry 7(5): 663-673, 1957

Pathogenesis of degenerative temporomandibular joint arthritides. Odontology 93(1): 7, 2005

Does Sleep Quality Affect Temporomandibular Joint With Degenerative Joint Changes?. Journal of Oral and Maxillofacial Surgery 77(8): 1594-1601, 2019

Degenerative disease of the temporomandibular joint. Journal of Orofacial Pain 9(2): 168-180, 1995

Natural history of degenerative joint disease in small laboratory animals. I. Pathologic anatomy of degenerative joint disease in mice. Arch Pathol 62(2): 118-128, 1956

Correlation between MRI evidence of degenerative condylar surface changes, induction of articular disc displacement and pathological joint sounds in the temporomandibular joint. Gerodontology 25(4): 251-257, 2008

Changes in the Temporomandibular Joints with Age (Degenerative Joint Disease). Periodontics 3: 184-189, 1965

Experimental degenerative temporomandibular joint disease. International Journal Of Oral & Maxillofacial Surgery. 23(6 Part 2): 423-424, 1994