+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Progressive supranuclear palsy and corticobasal ganglionic degeneration: differentiation by clinical features and neuroimaging techniques



Progressive supranuclear palsy and corticobasal ganglionic degeneration: differentiation by clinical features and neuroimaging techniques



Journal of Neural Transmission. Supplementum 42: 79-90



To assess the extent of overlap between clinically diagnosed patients with progressive supranuclear palsy (PSP) and corticobasal ganglionic degeneration (CBGD) we compared clinical scores for rigidity, bradykinesia, supranuclear gaze abnormalities, hemineglect and limb apraxia, postural instability, neck rigidity, and limb dystonia in 15 patients with a degenerative rigid-akinetic syndrome at presentation and at follow-up 3 to 120 months later. Only the presence of hemineglect, usually in combination with limb apraxia, was a reliable and early clinical factor for discriminating between these two conditions. These symptoms were present at admission in all 4 CBGD patients but not in any of the 11 PSP patients either at presentation or later during serial examinations. Though supranuclear ophthalmoplegia, neck rigidity, and postural instability were already observed in most CBGD patients at presentation, their scores remained low compared to those for PSP patients over the longterm. CT-scans and MRI were helpful in supporting clinically-based diagnoses made at presentation in that the vast majority of the PSP patients exhibited various degrees of midbrain atrophy and 50 percent of the CBGD patients exhibited asymmetric pericentral cortical atrophy.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 032983599

Download citation: RISBibTeXText

PMID: 7964699


Related references

Neuroimaging features in progressive supranuclear palsy and corticobasal degeneration. Rinsho Shinkeigaku 42(11): 1158-1161, 2002

A case with clinical features of progressive supranuclear palsy with apraxia--corticobasal degeneration?. Rinsho Shinkeigaku 34(11): 1168-1170, 1994

Corticobasal ganglionic degeneration and progressive supranuclear palsy presenting with cognitive decline. Brain Pathology. 8(2): 355-365, Il, 1998

The use of neuroimaging to diagnose patients with progressive supranuclear palsy and corticobasal degeneration. Neurology 58(7 Suppl. 3): A488, 2002

Clinical features differentiating patients with postmortem confirmed progressive supranuclear palsy and corticobasal degeneration. Journal of Neurology 246(Suppl. 2): II/1-II/5, 1999

Dual pathology of corticobasal degeneration and Parkinson's disease in a patient with clinical features of progressive supranuclear palsy. Neurology India 59(6): 887-890, 2012

Neuropathological features in corticobasal degeneration and progressive supranuclear palsy. Rinsho Shinkeigaku 42(11): 1155-1157, 2002

Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of Neurology 246(Suppl. 2): II/6-II/15, 1999

Co-occurrence of radiological features of progressive supranuclear palsy and corticobasal degeneration. Neurology India 55(1): 75-77, 2007

Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. JAMA Neurology 73(6): 733-742, 2016

Corticobasal degeneration and progressive supranuclear palsy--differentiation by somatosensory-evoked potentials. No to Shinkei 48(3): 253-257, 1996

An unusual autopsy case of corticobasal degeneration--with special reference to clinicopathological differentiation from progressive supranuclear palsy and slowly progressive aphasia. No to Shinkei 48(6): 559-565, 1996

A case manifested overlapping neuropathologic features of both progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). No to Shinkei 50(3): 263-271, 1998

A case manifested overlapping neuropathologic features of both progressive supranuclear palsy and corticobasal degeneration. Brain & Nerve (Tokyo) 50(3): 263-271, 1998

Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: Differentiation from progressive supranuclear palsy. Acta Neuropathologica 90(1): 37-43, 1995