+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome

Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome

Archives of Ophthalmology 110(12): 1757-1762

Evidence is increasing that pseudoexfoliative material develops in widespread areas of skin and parabulbar tissues as well as intraocularly. To determine whether this process is even more diffusely distributed, ultrastructural examination was performed on visceral and ocular tissues of a patient with long-standing glaucoma found to have bilateral ocular pseudoexfoliation at autopsy. Aggregates consistent with pseudoexfoliative material were present in the lung, heart, liver, and gallbladder, in addition to the classic intraocular sites. The aggregates were in the fibrovascular septa and stroma of these organs, most frequently adjacent to elastic and oxytalan fibers. They stained positively for elastin and human amyloid P protein, like the ocular sites, in preliminary immunologic testing. Rare atypical aggregates were seen in one of the four control patients. These findings suggest that pseudoexfoliation is a systemic process involving abnormal matrix synthesis, particularly as related to elastic tissue components.

(PDF emailed within 0-6 h: $19.90)

Accession: 033019920

Download citation: RISBibTeXText

PMID: 1463419

DOI: 10.1001/archopht.1992.01080240097039

Related references

Pseudoexfoliative fibrillopathy in the skin of patients with ocular pseudoexfoliation. American Journal of Ophthalmology 110(5): 490-499, 1990

Pseudoexfoliation syndrome Further evidence of a systemic fibrillopathy with a major component of fibrillin 15. Investigative Ophthalmology & Visual Science 35(4): 1785, 1994

Pseudoexfoliative fibrillopathy. Ophthalmology 95(6): 855-855, 1988

Pseudoexfoliation syndrome and pseudoexfoliative glaucoma. Optometry 75(4): 245-250, 2004

Amyloid P protein in pseudoexfoliative fibrillopathy. Current Eye Research 8(2): 217-227, 1989

Conjunctival impression cytology in pseudoexfoliative glaucoma and pseudoexfoliation syndrome. Clinical & Experimental Ophthalmology 34(2): 108-113, 2006

Retrobulbar hemodynamic parameters in pseudoexfoliation syndrome and pseudoexfoliative glaucoma. Graefe's Archive for Clinical and Experimental Ophthalmology 246(9): 1341-1349, 2008

Occurrence of pseudoexfoliative material in parabulbar structures in pseudoexfoliation syndrome. Acta Ophthalmologica 69(1): 124-130, 1991

Correlation of pseudoexfoliative material and optic nerve damage in pseudoexfoliation syndrome. Investigative Ophthalmology & Visual Science 38(12): 2435-2446, 1997

Pseudoexfoliative fibrillopathy in the conjunctiva. A relation to elastic fibers and elastosis. Ophthalmology 94(11): 1439-1449, 1987

Corneal biomechanical comparison of pseudoexfoliation syndrome, pseudoexfoliative glaucoma and healthy subjects. Current Eye Research 40(5): 470-475, 2016

Histological features of pseudoexfoliative material after cataract surgery in a case of pseudoexfoliation syndrome. Rinsho Ganka 51(7): 1393-1396, 1997

Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. Investigative Ophthalmology & Visual Science 47(5): 1982-1990, 2006

Pseudoexfoliative material on the IOL surface and development of glaucoma after cataract surgery in patients with pseudoexfoliation syndrome. Journal of Cataract and Refractive Surgery 33(10): 1815-1818, 2007

Aqueous humor and serum erythropoietin levels in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma. International Ophthalmology 30(6): 669-674, 2011