EurekaMag.com logo
+ Site Statistics
References:
54,215,046
Abstracts:
30,230,908
PMIDs:
28,215,208
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Recurrent glioblastoma multiforme: potential benefits using fractionated stereotactic radiotherapy and concurrent taxol



Recurrent glioblastoma multiforme: potential benefits using fractionated stereotactic radiotherapy and concurrent taxol



Stereotactic and Functional Neurosurgery 69(1-4 Pt 2): 162-174



A pilot protocol to treat recurrent glioblastoma was developed using fractionated stereotactic radiosurgery with concurrent intravenous Taxol as a radiation sensitizer. The treatment outcome was analyzed in two groups of patients with recurrent glioblastoma. Group 1 was analyzed retrospectively, and consisted of 9 patients with a median tumor volume of 9.2 cm3 treated with single-fraction stereotactic radiosurgery alone (mean radiation dose of 19.2 Gy). In group 2, prospectively analyzed, were 14 patients treated with fractionated stereotactic radiotherapy and concurrent Taxol. The median survival in group 2 was 14.2 months versus 6.3 months in group 1 (p < 0.04). One-year survival for patients who received fractionated radiotherapy with Taxol was 50% compared to 11% for those treated with single-fraction radiotherapy only (p = 0.05). Survival for group 2 patients was significantly better compared to those treated with single-fraction radiotherapy alone. These data should stimulate the investigation of both fractionated stereotactic radiotherapy and the development of radiation sensitizers to further enhance treatment.

(PDF emailed within 0-6 h: $19.90)

Accession: 033119682

Download citation: RISBibTeXText

PMID: 9711751

DOI: 10.1159/000099870



Related references

Treatment of recurrent glioblastoma multiforme (RGM): Fractionated stereotactic radiosurgery (FSR) and concurrent taxol (T). International Journal of Radiation Oncology*biology*physics 42(1-Supp-S1): 268-0, 1998

Improved survival using fractionated stereotactic irradiation and concurrent taxol for recurrent glioblastoma multiforme. Kondziolka, D Radiosurgery; Radiosurgery, 1997 110-113, 1998

Fractionated stereotactic radiosurgery and concurrent taxol in recurrent glioblastoma multiforme: A preliminary report. International Journal of Radiation Oncology Biology Physics 40(3): 661-666, 1998

Fractionated stereotactic radiosurgery and Taxol for recurrent glioblastoma multiforme. International Journal of Radiation Oncology Biology Physics 51(3 Supplement 1): 254, 2001

Fractionated stereotactic radiosurgery and taxol (FSR/T) for Recurrent Glioblastoma Multiforme (RGBM). International Journal of Radiation Oncology*biology*physics 51(3-Supp-S1): 254-0, 2001

Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy for the treatment of recurrent glioblastoma multiforme. Neurosurgical Focus 27(6): E8-E8, 2009

Treatment of recurrent glioblastoma multiforme using fractionated stereotactic radiosurgery and concurrent paclitaxel. American Journal of Clinical Oncology 23(2): 155-159, 2000

Fractionated stereotactic radiosurgery with concurrent temozolomide chemotherapy for locally recurrent glioblastoma multiforme: a prospective cohort study. Oncotargets and Therapy 7: 485-490, 2014

Salvage Fractionated Stereotactic Radiotherapy with or without Chemotherapy and Immunotherapy for Recurrent Glioblastoma Multiforme: A Single Institution Experience. Frontiers in Oncology 5(): 106-106, 2015

Stereotactic radiosurgery versus fractionated stereotactic radiotherapy boost for patients with glioblastoma multiforme. Technology in Cancer Research & Treatment 3(1): 41-49, 2004

Fractionated stereotactic radiosurgery and taxol for recurrent glioblastoma. International Journal of Radiation Oncology Biology Physics 54(2 Supplement): 246-247, 2002

Fractionated stereotactic radiosurgery and taxol (FSR/T) for recurrent glioblastoma (RGBM). International Journal of Radiation Oncology*biology*physics 54(2-Supp-S): 246-247, 2002

Fractionated stereotactic reirradiation and concurrent temozolomide in patients with recurrent glioblastoma. Journal of Neuro-Oncology 103(3): 683-691, 2011

Lack of survival benefit after stereotactic radiosurgery boost for glioblastoma multiforme: randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of radiation therapy oncology group 93-05 protocol: in regard to Souhami et al. (Int J Radiat Oncol Biol Phys 2004;60:853-860). International Journal of Radiation Oncology, Biology, Physics 62(1): 296-7; Author Reply 297, 2005

Adjuvant stereotactic fractionated radiotherapy to the resection cavity in recurrent glioblastoma - the GlioCave study (NOA 17 - ARO 2016/3 - DKTK ROG trial). Bmc Cancer 18(1): 15-15, 2018