+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Scaling up the spray drying process from pilot to production scale using an atomized droplet size criterion

Scaling up the spray drying process from pilot to production scale using an atomized droplet size criterion

Pharmaceutical Research 25(7): 1610-1620

The purpose of this study was to investigate the possibility of producing identical powders in pilot and production scale spray drying equipment by matching the droplet size distributions produced by two differently sized atomizers. Particles were prepared by spray drying solutions of acetaminophen and polyvinylpyrrolidone K-30. The success of the up-scaling was evaluated by comparing the powders in terms of particle size distribution (laser diffraction), crystallinity (XPRD) and morphology (SEM). Furthermore, the influence of process parameters on other product characteristics such as stability and residual volatile content was also evaluated. The spray drying experiments resulted in spherical, amorphous particles with volumetric median diameters of typically 4-10 microm for pilot scale and 4-30 microm for production scale. The results showed that particles with similar morphology and crystallinity could be produced in the two applied spray dryers. However, scale-up based purely on matching droplet size distributions was not feasible. The scale-up criterion did not account for the differences between the droplet-drying gas mixing and residence time distribution within the two spray dryers. Therefore, production scale experiments are required in order to obtain similar product characteristics as in pilot scale.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 033299231

Download citation: RISBibTeXText

PMID: 18404252

DOI: 10.1007/s11095-008-9565-8

Related references

Top-spray fluid bed coating: Scale-up in terms of relative droplet size and drying force. Powder Technology 184(3): 318-332, 2008

Kilogram-scale production of SnO(2) yolk-shell powders by a spray-drying process using dextrin as carbon source and drying additive. Chemistry 20(19): 5835-5839, 2014

Morphology and Particle Size Distribution Controls of Droplet-to-Macroporous/Hollow Particles Formation in Spray Drying Process of Colloidal Mixtures Precursor. Aerosol Science & Technology 43(12): 1184-1191, 2009

Optimisation of a pilot-scale spray drying process for probiotic yoghurt, using response surface methodology. International Journal of Dairy Technology 67(2): 211-219, 2014

Spray drying of concentrated milk; relation between initial droplet size and final particle size. Preconcentration and drying of food materials Conference Eindhoven, Netherlands 5-6 Nov 1987: 193-202, 1988

Particle drying and crystallization characteristics in a low velocity concurrent pilot scale spray drying tower. Powder Technology 223: 39-45, 2012

Sodium pantoprazole-loaded enteric microparticles prepared by spray drying: effect of the scale of production and process validation. International Journal of Pharmaceutics 324(1): 10-18, 2006

Production of Dissolvable Microneedles using an Atomized Spray Process Effect of Microneedle Composition on Skin Penetration. European Journal of Pharmaceutics and Biopharmaceutics, 2013

Investigation of the physical scaling of sea spray spume droplet production. Journal of Geophysical Research 114.C10, 2009

Catching method of spray droplet and distribution of spray droplet size in greenhouse low volume application. Journal of the Society of Agricultural Machinery, Japan 45(1): 63-70, 1983

Effect of shear rate and oxygen stresses on the survival of Lactococcus lactis during the atomization and drying stages of spray drying A laboratory and pilot scale study. Journal of Food Engineering 113(2), 2012

Droplet and particle size relationship and shell thickness of inhalable lactose particles during spray drying. Journal of Pharmaceutical Sciences 92(4): 900-910, 2003

Droplet size measurements for spray dryer scale-up. Pharmaceutical Development and Technology 13(2): 93-104, 2008

Effects of spray drying process parameters on the solubility behavior and physical stability of solid dispersions prepared using a laboratory-scale spray dryer. Drug Development and Industrial Pharmacy 39(9): 1484-1493, 2013

Spray Droplet Characterization from a Single Nozzle by High Speed Image Analysis Using an In-Focus Droplet Criterion. Sensors 16(2): 218, 2017