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Segmental neurofibromatosis: immunocytochemical analysis of cutaneous lesions



Segmental neurofibromatosis: immunocytochemical analysis of cutaneous lesions



Journal of the American Academy of Dermatology 22(4): 617-621



Cutaneous lesions from three patients with segmental neurofibromatosis were evaluated. Routine histologic studies revealed the presence of redimentary neural structures within an abundant collagenous matrix. The majority of the cells in all three cases expressed S-100 protein, suggesting their identity as Schwann cells. The stromal component stained positively for fibronectin and type IV collagen; the latter indicated the presence of basement membrane material. Embedded in the tumor mass were glandular epithelial structures that stained with epithelial membrane antigen antibody. Staining for factor VIII-related antigen revealed vascular endothelium and multiple scattered mast cells. In one case strands of cells stained with antibodies to desmin, suggesting muscle cell differentiation. This case may represent a distinct subset of neurofibromas.

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Accession: 033324789

Download citation: RISBibTeXText

PMID: 2108195

DOI: 10.1016/0190-9622(90)70083-t


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