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Sleep oscillations in corticothalamic neuronal networks and their development into self-sustained paroxysmal activity

Sleep oscillations in corticothalamic neuronal networks and their development into self-sustained paroxysmal activity

Romanian Journal of Neurology and Psychiatry 31(3-4): 151-161

Electrophysiological studies in cats have shown that one of the most common forms of sleep oscillation, spindling, may develop into spike-and-wave discharges through repetitive spike-bursts transmitted along thalamocortical or corticothalamic axons. The lowered frequency (from around 10 Hz to 3 Hz) can be explained by the abnormally increased duration of an IPSP mediated by GABA receptors. The administration of ethosuximide has a twofold effect resulting in a diminished spindling activity of the reticular thalamic nucleus as well as a decrease in the incidence of epileptic spike-and-wave discharges. Self-sustained paroxysmal activity may develop during EEG synchronized states by repetitively setting into action reciprocally connected structures.

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Accession: 033411093

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PMID: 8011479

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