EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Sleep polygraphy in schizophrenia: methodological issues



Sleep polygraphy in schizophrenia: methodological issues



Biological Psychiatry 28(3): 240-246



The findings of sleep studies in schizophrenia have remained inconsistent in the literature as exemplified by the recent controversy regarding reduced rapid eye movements (REM) latency in these patients. These inconsistencies can partly be explained by major methodological shortcomings in studies evaluating sleep in schizophrenia. Lack of standardized scoring and diagnostic methods in the earlier studies and more recently, the effect of neuroleptic treatment or its withdrawal, have confounded the sleep results. Data are presented to illustrate the effect of the presence of tardive dyskinesia or active psychotic symptoms that further skew the sleep polygraphic measurements in these patients. Studies in drug-naive patients can circumvent some of these confounds but then these studies are weakened by sampling bias. Available data suggest that previous duration of neuroleptic treatment, duration of neuroleptic withdrawal, presence of tardive dyskinesia, and severity of psychotic symptoms should be considered when interpreting REM sleep measures in schizophrenic patients.

(PDF emailed within 0-6 h: $19.90)

Accession: 033411146

Download citation: RISBibTeXText

PMID: 1974153

DOI: 10.1016/0006-3223(90)90579-q



Related references

Respiratory polygraphy in sleep apnoea diagnosis. Report of the Swiss respiratory polygraphy registry and systematic review of the literature. Swiss Medical Weekly 137(5-6): 97-102, 2007

Cytokines in schizophrenia: methodological issues. Schizophrenia Research 166(1-3): 360-361, 2016

Methodological issues of hemodialysis in schizophrenia. Psychopharmacology Bulletin 15(4): 15-17, 1979

Methodological Issues in Cytokine Measurement in Schizophrenia. Indian Journal of Psychological Medicine 38(1): 6-9, 2016

Methodological issues in the neuropsychological approach to schizophrenia. Nasrallah, H A And D R Weinberger (Ed ) Handbook Of Schizophrenia, Vol 1 The Neurology Of Schizophrenia Xii+416p Elsevier Science Publishers B V : Amsterdam, Netherlands (Dist in Usa And Canada By Elsevier Science Publishing Co Inc : New York, New York, Usa) Illus 141-156, 1986

Sensory gating and schizophrenia Critical methodological issues. Biological Psychiatry 35(9): 629, 1994

Atypical handedness in schizophrenia: some methodological and theoretical issues. Schizophrenia Bulletin 25(1): 63-78, 1999

Stressful life events and schizophrenia. II: Conceptual and methodological issues. British Journal of Psychiatry 162: 166-174, 1993

Dream research in schizophrenia: methodological issues and a dimensional approach. Consciousness and Cognition 20(4): 1036-1041, 2012

Medication effects conceptual and methodological issues in schizophrenia research. Clinical Psychology Review 12(3): 345-361, 1992

Preventing schizophrenia and psychotic behaviour: definitions and methodological issues. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie 47(6): 527-537, 2002

The Philosophical Relevance of the Study of Schizophrenia. Methodological and Conceptual Issues. Revista Colombiana de Psiquiatria 43(3): 168-174, 2014

Infant sleep interventions - Methodological and conceptual issues. Sleep Medicine Reviews 29: 123-125, 2016

Brain mechanisms of sleep an overview of methodological issues. Unknown, 1985

Sleep of excessively crying infants: a 24-Hour Ambulatory Sleep Polygraphy study. Pediatrics 114(3): 592-600, 2004