Structural elucidation of the specific capsular polysaccharide of Rhodococcus equi serotype 7

Masoud, H.; Richards, J.C.

Carbohydrate Research 252: 223-233


ISSN/ISBN: 0008-6215
PMID: 8137362
DOI: 10.1016/0008-6215(94)90017-5
Accession: 033515701

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Structural analysis of the specific capsular polysaccharide produced by Rhodococcus equi serotype 7 indicated it to be a high-molecular-weight polymer consisting of equal molar amounts of D-galactose, D-mannose, L-rhamnose, and pyruvic acid. By employing a combination of chemical and NMR techniques, it was established that the polysaccharide is composed of the linear repeating trisaccharide units: [formula: see text] -->3)-alpha-D-Galp-(1-->3)-alpha-D-Manp-(1-->3)-alpha-L-Rhap -(1-->, in which the cyclic pyruvic acid acetal groups bridging the O-4 and O-6 positions of the alpha-D-Manp residues have the S-configuration. The 1H and 13C NMR spectra of the native and pyruvic acetal-free polysaccharides were fully assigned.