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The cellular mechanism of action by vasoconstrictor hormones in cultured rat vascular smooth muscle cells


The cellular mechanism of action by vasoconstrictor hormones in cultured rat vascular smooth muscle cells



American Journal of Hypertension 3(8 Part 2): 227s-230s



ISSN/ISBN: 0895-7061

PMID: 2222973

DOI: 10.1093/ajh/3.8.227

The effects of angiotensin (Ang) II, arginine vasopressin (AVP), and serotonin (5-HT) on inositol trisphosphate (IP3) production, cytosolic Ca2+ concentration [( Ca2+]i), and the phosphorylation of 20 kilodalton myosin light chain (MLC) were examined in cultured rat vascular smooth muscle cells (VSMC). These vasoconstrictors immediately induced dose-dependent and concomitant increases in IP3 production, [Ca2+]i, and phosphorylation of 20 kDa MLC. The agonist-induced increases in IP3 production, [Ca2+]i, and phosphorylation of 20 kDa MLC in VSMC were completely blocked by pretreatment with the receptor antagonists for Ang II, V1, and 5-HT2, respectively. These data suggest that receptor-mediated increases in IP3 production, [Ca2+]i, and phosphorylation of 20 kDa MLC by these vasoconstrictors are closely interrelated.

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Accession: 033733577

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