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The effect of temperature on the effectiveness of acetylcholine activity



The effect of temperature on the effectiveness of acetylcholine activity



Doklady Akad Nauk Sssr 102(2): 323-326



The effect of temperature on the sensitivity to acetylcholine in concentrations of 10-4 to 10-8.5 was studied on the isolated cardiac ventricle of frogs. At 0 the ventricle is not sensitive. The sensitivity of the myocardium increases with increase in temperature, reaching a maximum at 15-25[degree]. At 38-40[degree] the reaction of the ventricle to acetylcholine ceases again. An analogous relationship exists in the heart of the gopher, but the maximal reaction was at temperatures of 35-38[degree]. The form of the relationship of the effectiveness of the activity of acetylcholine with temperature resembles the curve of the changes of the activity of enzymes and forms a basis for the belief that, in the case of its action on the effector structures, acetylcholine interacts with protein. This indicates an irreversibility of the loss of sensitivity of the cardiac muscles after warming to a temperature of 40-41[degree] for 10-20 minutes, since an irreversible denaturation of the protein bodies of the effectors of the structure of the myocardium which are responsible for the appearance of the activity of acetylcholine could occur at this time.

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Accession: 033785062

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