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The effect of the combination therapy with sucralfate and famotidine on experimentally induced duodenal ulcers in rats



The effect of the combination therapy with sucralfate and famotidine on experimentally induced duodenal ulcers in rats



Pflugers Archiv 431(6 Suppl 2): R215-R216



The combination of sucralfate (SUC) and famotidine (FAM) at subtherapeutic dose on cysteamine-induced duodenal ulcers (3 x 250 mg/kg) in female rats was studied. Subtherapeutic doses were determined in the preliminary studies. They were 200 mg/kg SUC and 0.2 mg/kg FAM (twice a day). The macroscopic examination was done 24 hours after first application of cysteamine. The effectiveness of SUC and FAM combination in subtherapeutic doses was confirmed by decreased number (from 1.3 to 0.5), length (from 5.5 mm to 1.9 mm), severity of duodenal ulcers (from 3.4 to 1.2) and reduction of ulcerative index by 54.4%.

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Accession: 033785444

Download citation: RISBibTeXText

PMID: 8739341

DOI: 10.1007/BF02346345



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