+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia



The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia



Journal of Psychopharmacology 22(3): 308-322



Group II metabotropic glutamate receptors (mGluRs) comprise mGluR2 (mGlu2; encoded by GRM2) and mGluR3 (mGlu3; encoded by GRM3) and modulate glutamate neurotransmission and synaptic plasticity. Here we review the expression and function of mGluR3 and its involvement in schizophrenia. mGluR3 is expressed by glia and neurons in many brain regions and has a predominantly presynaptic distribution, consistent with its role as an inhibitory autoreceptor and heteroceptor. mGluR3 splice variants exist in human brain but are of unknown function. Differentiation of mGluR3 from mGluR2 has been problematic because of the lack of selective ligands and antibodies; the available data suggest particular roles for mGluR3 in long-term depression, in glial function and in neuroprotection. Some but not all studies find genetic association of GRM3 polymorphisms with psychosis, with the risk alleles also being associated with schizophrenia-related endophenotypes such as impaired cognition, cortical activation and glutamate markers. The dimeric form of mGluR3 may be reduced in the brain in schizophrenia. Finally, preclinical findings have made mGluR3 a putative therapeutic target, and now direct evidence for antipsychotic efficacy of a group II mGluR agonist has emerged from a randomised clinical trial in schizophrenia. Together these data implicate mGluR3 in aetiological, pathophysiological and pharmacotherapeutic aspects of the disorder.

(PDF emailed within 0-6 h: $19.90)

Accession: 033825306

Download citation: RISBibTeXText

PMID: 18541626

DOI: 10.1177/0269881108089818


Related references

Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study. Schizophrenia Research 177(1-3): 18-27, 2016

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding. Journal of Psychopharmacology 31(12): 1519-1526, 2017

Association analysis of the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Psychiatric Genetics 17(6): 358, 2007

Association studies of the metabotropic glutamate receptor genes, GRM3 and GRM4, with schizophrenia. American Journal of Medical Genetics 114(7): 875, October 8, 2002

Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Psychiatric Genetics 13(2): 71-76, 2003

Association study of polymorphisms in two metabotropic glutamate receptor genes, GRM3 and GRM8 with schizophrenia. American Journal of Human Genetics 73(5): 534, 2003

No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population. Schizophrenia Research 88(1-3): 260-264, 2006

Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. American Journal of Medical Genetics 114(1): 46-50, 2002

Association between type-three metabotropic glutamate receptor gene (GRM3) variants and symptom presentation in treatment refractory schizophrenia. Human Psychopharmacology 26(1): 28-34, 2013

Modulation of epileptiform burst frequency and duration by the group II metabotropic glutamate receptor subtype mGluR3. Society for Neuroscience Abstracts 26(1-2): Abstract No -274 4, 2000

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice. Bmc Neuroscience 14: 102, 2014

Expression of a truncated secreted form of the mGluR3 subtype of metabotropic glutamate receptor. Biochemical and Biophysical Research Communications 319(2): 622-628, 2004

Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia. Psychopharmacology 232(1): 145-154, 2015

Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. Progress in Neuro-Psychopharmacology and Biological Psychiatry 33(5): 875-879, 2010

Group II metabotropic glutamate receptors (mGlu2 and mGlu3). 2008