+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

The Korsakoff syndrome: a neurochemical perspective

The Korsakoff syndrome: a neurochemical perspective

Trends in Neurosciences 13(8): 340-344

Korsakoff's disease is an amnesic syndrome associated with midline diencephalic and brain stem pathology. A number of neurochemical systems course through or near the loci of brain lesions found postmortem in Korsakoff patients, which has stimulated studies to learn whether these systems are implicated in amnesia. Data suggest that the loss of brain catecholamine function contributes to this amnesic syndrome and may also be a factor in the memory impairments associated with normal aging. At present, data are insufficient to determine whether cholinergic systems are disturbed in Korsakoff's patients; however, it is likely that multiple neurochemical abnormalities underlie this disorder.

(PDF emailed within 0-6 h: $19.90)

Accession: 033856484

Download citation: RISBibTeXText

PMID: 1699320

DOI: 10.1016/0166-2236(90)90146-2

Related references

An international perspective on the prevalence of the Wernicke-Korsakoff syndrome. Metabolic Brain Disease. 10(1): 17-24, 1995

Perspective taking in Korsakoff's syndrome: the role of executive functioning and task complexity. Acta Neuropsychiatrica 23(6): 302-308, 2011

The mammillary bodies and Korsakoff's syndrome; anatomical study of eight cases of Korsakoff's syndrome of alcoholic origin without any significant changes in the cerebral cortex. I. Anatomo-clinical study. La Presse Medicale 66(83): 1849-1852, 1958

The mammillary bodies & Korsakoff's syndrome; anatomical study of 8 cases of Korsakoff's syndrome of alcoholic origin without significant alteration of the cerebral cortex. II. Mammillary tubercules & memory mechanism. La Presse Medicale 66(88): 1965-1968, 1958

Korsakoff's syndrome caused by aneurysm of the anterior communicating artery; the problem of Korsakoff's syndrome caused by meningeal hemorrhage. Revue Neurologique 118(4): 293-299, 1968

Some behavioral consequences of neurochemical deficits in korsakoff psychosis. Squire, L R And N Butters (Ed ) Neuropsychology Of Memory Xv+655p The Guilford Press: New York, N Y , Usa; London, England Illus 224-235, 1984

Neurochemical pathology in Korsakoff's psychosis: implications for other cognitive disorders. Neurology 34(5): 648-652, 1984

Confabulatory syndrome and delusion of grandeur; evolution of post-traumatic Korsakoff syndrome. Rivista Sperimentale di Freniatria E Medicina Legale Delle Alienazioni Mentali 81(1): 244-253, 1957

Amnestic syndrome and Korsakoff's syndrome--two anatomically and topically differentiable syndromes?. Der Nervenarzt 42(8): 402-413, 1971

Comparisons of Korsakoff and non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioning. Alcoholism, Clinical and Experimental Research 28(4): 667-675, 2004

Frontal lobe and visuospatial memory function in korsakoff and non korsakoff alcoholics. Society for Neuroscience Abstracts 15(1): 244, 1989

Frontal lobe function in Korsakoff and non-Korsakoff alcoholics: planning and spatial working memory. Neuropsychologia 29(8): 709-723, 1991

Memory deficits in Korsakoff and non-Korsakoff alcoholics following alcohol withdrawal and the relationship to length of abstinence. Alcohol and Alcoholism . Supplement 2: 501-505, 1993

Visual and auditory spatial and nonspatial delayed-response performance by Korsakoff and non-Korsakoff alcoholic and aging individuals. Behavioral Neuroscience 106(4): 613-622, 1992