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Treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine aids maids


, : Treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine aids maids. Antiviral Research (SUPPL 1): 111


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Gangemi J.D.; Decastro L.; Ghaffar A.; Mayer E.P.; Kern E.R., 1990: Treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine aids maids therapy with 9 2 phosphonylmethoxyethyladenine pmea. Journal of Cellular Biochemistry Supplement (14 PART D): 65

D.C.stro, L.M.; Kern, E.R.; D.C.ercq, E.; Ghaffar, A.; Mayer, E.P.; Vogt, P.E.; Gangemi, J.D., 1991: Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. Murine acquired immunodeficiency syndrome (MAIDS) was induced in C57BL/6 mice following infection with the LP-BM5 retrovirus complex. Infected mice developed splenomegaly, lymphadenopathy and loss of B- and T-cell functions 100 days after virus in...

Gangemi, J.D.; Cozens, R.M.; D.C.ercq, E.; Balzarini, J.; Hochkeppel, H.K., 1989: 9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections. The murine model of acquired immunodeficiency disease was used to evaluate both the antiretroviral and antiherpetic activities of the acyclic nucleotide analog 9-(2-phosphonylmethoxyethyl)adenine (PMEA). The antiretroviral activity of PMEA was com...

Nishiyama, Y.; Yamamoto, N.; Yamada, Y.; Fujioka, H.; Shimada, N.; Takahashi, K., 1989: Efficacy of oxetanocin G against herpes simplex virus type 2 and murine cytomegalovirus infections in mice. Journal of Antibiotics 42(8): 1308-1311

Lee, J.Y.; Peel, R., 1989: Concurrent cytomegalovirus and herpes simplex virus infections in skin biopsy specimens from two AIDS patients with fatal CMV infection. Cytomegalovirus (CMV) infection involving the skin is rare. Only a few cases have been documented by skin biopsies, including three patients with acquired immunodeficiency syndrome (AIDS). We report concurrent CMV and herpes simplex virus (HSV) in...

Palmer M.; Taylor J.L.; O'brien W.J.; Punda Polic V.; Fritz R.B.; Grossberg S.E., 1991: Herpes simplex virus infection in a murine model of acquired immune deficiency syndrome maids. Investigative Ophthalmology & Visual Science 32(4): 764

Yokota, Y.; Watanabe, Y.; Wakai, Y.; Mine, Y., 1992: Protective effects of immunoactive peptide, FK565 against systemic and local infections with herpes simplex virus and murine cytomegalovirus and respiratory tract infection with influenza virus in mice. The protective effects of FK565 against systematic infections with herpes simplex virus (HSV) and murine cytomegalovirus (MCMV), respiratory tract infection with influenza virus and zosteriform rash with HSV investigated in mice. FK565 showed exce...

Heise, M.T.; Virgin, H.W., 1995: The T-cell-independent role of gamma interferon and tumor necrosis factor alpha in macrophage activation during murine cytomegalovirus and herpes simplex virus infections. We defined the normal and innate (without functional B or T cells) inflammatory response to infection with mouse cytomegalovirus (MCMV) or herpes simplex virus (HSV). Intraperitoneal infection with MCMV or HSV induced an inflammatory infiltrate co...

James, S.H.; Kimberlin, D.W.; Whitley, R.J., 2009: Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection. Herpesvirus infections of the central nervous system (CNS) are a significant cause of morbidity and mortality, including long-term neurologic sequelae. Among the family of herpesviruses, the most significant CNS infections are due to herpes simple...

Glasgow L.A.; Kern E.R., 1980: Effective treatment of disseminated herpes simplex virus and cytomegalovirus infections of mice with 9 2 hydroxyethoxymethyl guanine acyclovir. Nelson, J D And C Grassi (Ed ) Current Chemotherapy And Infectious Disease, Vol 1 And 2; Proceedings Of The 11th International Congress And The 19th Interscience Conference on Antimicrobial Agents And Chemotherapy, Boston, Mass , Usa, Oct 1-5, 1979 Xxi+774p (Vol 1); Ix+1023p (Vol 2 ) The American Society For Microbiology: Washington, D C , Usa Illus P1394-1396