+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

Current Opinion in Cell Biology 7(2): 215-223

Rapid degradation of specific proteins by ubiquitin/proteaseome-dependent pathways is a component of many cellular regulatory mechanisms. Recent work has shown that protein ubiquitination and deubiquitination are both mediated by large families of enzymes and that proteolysis can be modulated by alterations of the proteasome itself. The complexity of the ubiquitin system is reflected in the broad range of processes it regulates; these include key steps in cell cycle progression, processing of foreign proteins for presentation by class I MHC molecules, and the control of cell proliferation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 034111511

Download citation: RISBibTeXText

PMID: 7612274

DOI: 10.1016/0955-0674(95)80031-x

Related references

Rpn4, a Novel Transcription Factor Participating in the Regulation of Ubiquitin-Dependent Protein Degradation by Proteasomes. Molecular Biology 38(4): 2, 2004

Direct ubiquitin independent recognition and degradation of a folded protein by the eukaryotic proteasomes-origin of intrinsic degradation signals. Plos one 7(4): E34864, 2012

Ubiquitin-independent protein degradation in proteasomes. Biomeditsinskaia Khimiia 64(2): 134-148, 2018

Proteasomes and the ubiquitin-dependent protein degradation pathway. Postepy Biologii Komorki 22(3): 295-315, 1995

The unfolding of substrates and ubiquitin-independent protein degradation by proteasomes. Biochimie 83(3-4): 311-318, 2001

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288(5467): 874-877, 2000

CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway. Journal of Virology 72(3): 2280-2288, 1998

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. Journal of Clinical Investigation 93(5): 2127-2133, 1994

Regulation of Protein Degradation by Proteasomes in Cancer. Journal of Cancer Prevention 23(4): 153-161, 2018

Regulation of protein degradation by cellular signaling pathways and manipulation of the ubiquitin-proteasome system with targeted protein degradation vehicles. Growth Hormone & IGF Research 14(2): 117, 2004

Ubiquitin and intracellular protein degradation. Current Opinion in Cell Biology 4(6): 1024-1031, 1992

Ubiquitin and the enigma of intracellular protein degradation. European Journal of Biochemistry 231(1): 1-30, 1995

Scope of the ATP--ubiquitin system for intracellular protein degradation. Febs Letters 143(2): 225-227, 1982

The ubiquitin and atp dependent pathway for intracellular protein degradation. Journal of Cellular Biochemistry Suppl. (10 Part A): 239, 1986

The ubiquitin-mediated system for intracellular protein degradation. Journal of Basic and Clinical Physiology and Pharmacology 2(3): 141-159, 1991