+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ursodeoxycholate alleviates alcoholic fatty liver damage in rats



Ursodeoxycholate alleviates alcoholic fatty liver damage in rats



Alcoholism, Clinical and Experimental Research 22(7): 1538-1543



The hydrophilic bile salt ursodeoxycholate (UDC) improves cholestasis in several liver diseases and is in vitro an efficient membrane stabilizer. However, its action on chronic ethanol-induced liver damage is not established. We thus sought to determine the effect of UDC on chronic ethanol-induced steatosis and on liver plasma membrane fluidity in rats. Male rats were pair-fed liquid diets containing 36% of calories as ethanol (alcohol diet) or an isocaloric maltose-dextrin mixture (control diet). Four groups of 10 animals received, respectively, during 30 days: the control diet, the control diet + UDC (90 mg/kg/day), the alcohol diet, and the alcohol diet + UDC. Bile was collected for assessment of bile flow, biliary lipids, and individual bile salts. Liver lipid contents and lipid peroxidation were determined. Plasma membrane fluidity was assessed by fluorescence polarization of various probes. Alcohol treatment caused a 4-fold increase in liver triacylglycerol and cholesterol ester levels. UDC supplementation significantly reduced these increases by 50% and 40%, respectively. UDC intake was associated with a marked decrease in alcohol-induced lipid peroxidation. Bile flow, bile salt, and phospholipid secretion were slightly increased by alcohol intake. The addition of UDC-enriched bile with tauroursodeoxycholate (38%) without significantly affecting the biliary parameters. Lastly, UDC treatment almost totally prevented the 20% increase in liver plasma membrane fluidity due to chronic alcohol intake. This study shows that UDC intake, concomitant with alcohol diet, exerts a clear-cut membrane protective effect that might alleviate ethanol-induced lipid disorders.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 034144750

Download citation: RISBibTeXText

PMID: 9802540

DOI: 10.1111/j.1530-0277.1998.tb03947.x


Related references

β-Lapachone alleviates alcoholic fatty liver disease in rats. Cellular Signalling 26(2): 295-305, 2014

Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c. Molecular Medicine Reports 6(4): 815-820, 2013

Houttuynia cordata alleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats. Pharmaceutical Biology 53(3): 414-422, 2015

Knockdown of hepatic aquaglyceroporin-9 alleviates high fat diet-induced non-alcoholic fatty liver disease in rats. International Immunopharmacology 15(3): 550-556, 2013

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. Journal of Hepatology 58(5): 993-999, 2014

Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model. International Journal of Molecular Medicine 36(3): 767-775, 2016

Resveratrol alleviates alcoholic fatty liver in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology 295(4): G833-G842, 2008

Alcohol-induced organic lesions. 3. Liver damage - alcoholic fatty liver, alcoholic hepatitis, acute and chronic clinical course. Fortschritte der Medizin 102(4): 79-82, 1984

Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice. Nutrition Research and Practice 8(2): 172-176, 2014

Effects of carbohydrate intake on the blood ethanol level and alcoholic fatty liver damage in rats. Journal Of Hepatology. 17(1): 97-101, 1993

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. Journal of Clinical Investigation 112(1): 91-100, 2003

Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease. Journal of Bioenergetics and Biomembranes 44(4): 439-452, 2012

Ursodeoxycholate alleviates alcohol-induced liver mitochondrial injury. Gastroenterology 114(4 PART 2): A1350, April 15, 1998

Damage to cell membranes in alcoholic and non-alcoholic fatty liver, and correction of it. Eksperimental'naia i Klinicheskaia Gastroenterologiia 1): 64-65, 2002

Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice. International Journal of Experimental Pathology 94(3): 217-225, 2013