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Use of cyclodextrins in capillary electrophoresis for the chiral resolution of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs

Use of cyclodextrins in capillary electrophoresis for the chiral resolution of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs

Journal of Chromatography A 694(1): 297-305

The enantiomeric separation of racemic compounds of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs (profens), namely fenoprofen, ibuprofen, flurbiprofen, suprofen, ketoprofen and indoprofen, was performed by capillary zone electrophoresis. The separation was obtained by supporting the background electrolyte with derivatized -cyclodextrins. The type and concentration of cyclodextrin used and the background electrolyte composition (pH and amount of methanol) influenced the complexation and the chiral resolution. All the modified -cyclodextrins used (heptakis-2,6-di-O-methyl--, heptakis-2,3,6-tri-O-methyl- and 6A-methylamino--cyclodextrin) showed good complexing effects with the profens tested. Tri-O-methyl--cyclodextrin proved to be the best stereoselective additive because it allowed the enantiomeric resolution of all the profens studied whereas the dimethylated and methylamino--cyclodextrin were able to separate only some of them.

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Accession: 034150761

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DOI: 10.1016/0021-9673(94)00945-6

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