+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Utilization of in vitro drug-drug interaction studies in drug discovery/development



Utilization of in vitro drug-drug interaction studies in drug discovery/development



Pharmaceutical Research (New York) 13(9 Suppl. ): S558




Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 034169435

Download citation: RISBibTeXText


Related references

Metabolism-based drug-drug interaction studies in drug discovery and development Attempting in vitro-in vivo correlations A report from the front line. Pharmaceutical Research (New York) 13(9 Suppl. ): S548, 1996

Establishment of in vitro P-glycoprotein inhibition assay and its exclusion criteria to assess the risk of drug-drug interaction at the drug discovery stage. Journal of Pharmaceutical Sciences 100(9): 4013-4023, 2011

Evaluation of the use of static and dynamic models to predict drug-drug interaction and its associated variability: impact on drug discovery and early development. Drug Metabolism and Disposition: the Biological Fate of Chemicals 40(8): 1495-1507, 2012

Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process. Drug Metabolism and Disposition: the Biological Fate of Chemicals 35(7): 1232-1238, 2007

Drug-Induced Phototoxicity; An Early In Vitro Identification of Phototoxic Potential of New Drug Entities in Drug Discovery and Development. Current Drug Safety 4(2): 123-136, 2009

Drug-induced phototoxicity; an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development. Current Drug Safety 4(2): 123-136, 2009

The application of in vitro models of drug metabolism and toxicity in drug discovery and drug development. Drug and Chemical Toxicology 18(1): 1-28, 1995

Drug-drug interaction potential of marketed oncology drugs: in vitro assessment of time-dependent cytochrome P450 inhibition, reactive metabolite formation and drug-drug interaction prediction. Pharmaceutical Research 29(7): 1960-1976, 2012

Predictive power of an in vitro system to assess drug interactions of an antimuscarinic medication: a comparison of in vitro and in vivo drug-drug interaction studies of trospium chloride with digoxin. Journal of Clinical Pharmacology 46(7): 776-784, 2006

Physical chemical drug-drug interactions from drug discovery to registration: new opportunities for the pharmaceutical scientist to impact drug development. Molecular Pharmaceutics 10(11): 3967-3969, 2013

Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. Journal of Pharmacological and Toxicological Methods 58(3): 206-214, 2008

In vitro human hepatocyte-based experimental systems for the evaluation of human drug metabolism, drug-drug interactions, and drug toxicity in drug development. Current Topics in Medicinal Chemistry 14(11): 1325-1338, 2014

Optimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery. Journal of Biomolecular Screening 12(1): 92-99, 2007

Drug-drug Interaction Discovery Using Abstraction Networks for "National Drug File - Reference Terminology" Chemical Ingredients. AMIA .. Annual Symposium Proceedings. AMIA Symposium 2015: 973-982, 2015

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potential. Drug Metabolism Reviews 42(1): 196-208, 2010