Section 35
Chapter 34,248

Withanolide Z, a new chlorinated withanolide from Withania somnifera

Pramanick, S.; Roy, A.; Ghosh, S.; Majumder, H.K.; Mukhopadhyay, S.

Planta Medica 74(14): 1745-1748


ISSN/ISBN: 0032-0943
PMID: 18988152
DOI: 10.1055/s-2008-1081357
Accession: 034247350

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Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z (1), along with four known withanolides, withanolide B (2), withanolide A (3), 27-hydroxywithanolide B (4) and withaferin A (5). Their structures were elucidated by IR, MS, CD and a combination of 1 D and 2 D NMR spectral analyses. The Leishmania donovani DNA topoisomerase I inhibitory activities of the isolated compounds were determined.

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