Section 35
Chapter 34,274

4 benzoic and 2 acetic acid, their esters and salts having cytochrome p450rai inhibitory activity

Vasudevan, J.; Wang, L.; Liu, X.; Tsang, K.Y.; Yuan, Y.D.; Chandraratna, R.S.

Official Gazette of the United States Patent and Trademark Office Patents 1282(4)


ISSN/ISBN: 0098-1133
Accession: 034273217

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Compounds of Formula 1: ##STR1## wherein the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with retinoids, or which are controlled by or responsive to the organism's native retinoic acid. Formulations containing the compounds of the invention can also be co-administered with retinoids and/or Vitamin A to enhance or prolong the effects of medications containing retinoids, Vitamin A, or of the organism's native retinoic acid.

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