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A novel skin cleansing technology that reduces bacterial attachment to the skin

A novel skin cleansing technology that reduces bacterial attachment to the skin

Abstracts of the General Meeting of the American Society for Microbiology 102: 399

To date, antibacterial skin cleansing products remove germs via detergency/mechanical action or by killing them with added antimicrobial agents. We report here a novel technology/formulation in soap that inhibits bacteria from attaching to the skin. This technology is composed of Petrolatum, Polyquaternium, and Dimethicone and termed as MAT (Microbial Anti-attachment Technology). Anti-attachment activity was tested against a range of Gram positive and Gram negative bacteria using porcine skin as a model substrate. Porcine skin samples were washed with soap with or without this technology; air dried and mounted on a sample stage. An aliquot of radio-labeled bacteria was applied on the skin. After a specified contact time, unattached bacteria were recovered and quantified by liquid scintillation counting. Results show 35-57% reduction in bacterial attachment to the skin washed with bar soap containing this technology vs. placebo. Anti-attachment activity was more pronounced against Gram negative Salmonella choleraesuis (57%) than the Gram positive S. aureus (42%). Scanning electron microscopy confirmed the radiochemistry results. Additionally, we investigated the contribution of each ingredient in MAT to the overall effect. Results show that comparatively fewer bacteria attached to the skin washed with Dimethicone or Petrolatum containing soaps. However, maximum anti-attachment activity was observed with the full formula suggesting a synergistic role of the combined ingredients. The clinical efficacy of MAT was confirmed by in vivo tests using human hands and Serratia marcescens as marker bacteria. Briefly, hands were washed with soap with or without MAT. After drying, hands were lightly pressed on surfaces pre-coated with the bacteria. Bacteria from hands were then collected and quantified. Statistically significant reduction (50%) in bacterial attachment was observed on the hands washed with MAT vs. placebo. We hypothesize that this technology deposits a thin layer of film on skin surface that blocks the sites for bacterial attachment. In conclusion, MAT provides a new paradigm in germ protection.

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Accession: 034312190

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