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A novel type of spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain optical evidence for intercellular communication in the developing CNS



A novel type of spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain optical evidence for intercellular communication in the developing CNS



Society for Neuroscience Abstracts 26(1-2): Abstract No -510 6



Throughout the experiments on multiple-site voltage-sensitive dye recordings of neural activity in embryonic chick brain preparations, we have found a novel type of depolarization waves which spread widely from the brainstem to the whole brain region at a rapid rate of (mm/sec). This depolarization wave was triggered by glutamate-mediated postsynaptic potentials and was especially correlated to N-methyl-D-aspartate receptor function. Evidence that the spreading depolarization wave is eliminated by octanol or 18beta-glycyrrhetinic acid suggests that the depolarization wave spreads electrotonically through gap junctions. The profile obtained with Ca2+-imaging experiments also suggests that the propagation of the depolarization wave induces a calcium wave. The experimental results provide new evidence for gap junction-mediated intercellular functional communication between neural cells in the vertebrate central nervous system during embryonic development.

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Accession: 034312674

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