+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

A novel vitamin e derivative protects aspirin induced gastric mucosal injury in rats



A novel vitamin e derivative protects aspirin induced gastric mucosal injury in rats



Digestive Disease Week Abstracts & Itinerary Planner : Abstract No S1204



There is strong evidence that oxygen-derived free radicals produced by neutrophils are implicated in the production of aspirin-induced gastric mucosal injury. It has been reported that a novel vitamin E derivative, 2-(alpha-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol (TMG), is somewhat located within the membrane surface and acts as a powerful antioxidant by scavenging radicals generated either in the aqueous or in the lipid phase. The purpose of this study was to investigate the antioxidative effects of water-soluble vitamin E derivative, TMG, which has excellent water-solubility (>1 x 103 mg/ml), on aspirin-induced gastric mucosal injury in rats. Aspirin-induced mucosal injury was produced by the intragastric administration of aspirin (200 mg / kg) and HCl (0.15 N, 8.0 ml / kg). At 3 h after administration of aspirin the animals were killed by exanguination via the abdominal aorta. TMG was dissolved in physiological saline at a dose of 0.1 - 10 mg/kg, and was given to the rats by intraperitoneal injection 1 h before the aspirin administration. The intragastric administration of acidified aspirin induced hyperemia and hemorrhagic erosions in rat stomachs. The increase in the total gastric erosive area after aspirin administration was significantly inhibited by treatment with TMG in a dose-dependent manner. The concentration of thiobarbituric acid-reactive substances (TBA-RS) in the gastric mucosa, an index of lipid peroxidation, was also significantly higher than the basal level after aspirin administration. This increase in TBA-RS in the gastric mucosa was inhibited by pretreatment with TMG. Furthermore, myeloperoxidase (MPO) activity in the gastric mucosa, an index of neutrophil infiltration, significantly increased by aspirin administration, and pretreatment with TMG significantly reduced this increase. The content of mucosal CINC-1 in the control groups was significantly increased compared with the levels of that in the sham groups. This increase of the level of CINC-1 was significantly inhibited by the treatment with TMG at a dose of 10 mg/kg. Based on these data, the beneficial effects of TMG on aspirin-induced gastric mucosal injury may be attributed to its anti-inflammatory properties.

(PDF emailed within 1 workday: $29.90)

Accession: 034312738

Download citation: RISBibTeXText


Related references

A novel water-soluble vitamin E derivative protects against aspirin-induced gastric mucosal injury in rats. International Journal of Molecular Medicine 16(6): 1035-1040, 2005

A novel vitamin E derivative (TMG) protects against gastric mucosal damage induced by ischemia and reperfusion in rats. Digestive Diseases and Sciences 48(1): 54-58, 2003

Effect of vitamin E on aspirin-induced gastric mucosal injury in rats. Digestive Diseases and Sciences 45(3): 599-605, 2000

A novel vitamin E derivative protects gastric mucosal damage induced by ischemia and reperfusion. Gastroenterology 118(4 Suppl 2 Part 1): A73, April, 2000

Vitamin E protects against stress-induced gastric mucosal lesions in rats more effectively than vitamin C. Biofactors 36(1): 60-69, 2010

Aspirin induced gastric mucosal injury in rats and adenyl cyclase. Biochemical Medicine 11(4): 376-382, 1974

Mucosal protective effects of vitamin E on aspirin-induced gastric lesions in rats. IJP International Journal of Pharmacology 1(1): 93-97, 2005

Age related changes in gastric mucosal prostaglandin pg synthesis and aspirin induced injury in rats. Gastroenterology 102(4 PART 2): A563, 1992

Role of fructose-1-6-diphosphate in aspirin-induced gastric mucosal injury in rats. Gastroenterology 104(4 SUPPL ): A60, 1993

Oral human spasmolytic polypeptide protects against aspirin-induced gastric injury in rats. Journal Of Gastroenterology & Hepatology. 13(4): 363-370, Il, 1998

Dietary fish oil protects against ethanol induced gastric mucosal injury in rats. Gastroenterology 94(5 PART 2): A123, 1988

Aspirin-induced acute gastric mucosal injury is a neutrophil-dependent process in rats. American Journal of Physiology 263(6 Pt 1): G920-G926, 1992