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A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone



A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone



Proceedings of the National Academy of Sciences of the United States of America 101(33): 12064-6



Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphilone under mild reaction conditions.

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Accession: 034312870

Download citation: RISBibTeXText

PMID: 15232001

DOI: 10.1073/pnas.0402563101


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