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Activity of lumbar dual projection neurons that contribute to dorsal spinocerebellar and spinoreticular tracts during sleep and wakefulness



Activity of lumbar dual projection neurons that contribute to dorsal spinocerebellar and spinoreticular tracts during sleep and wakefulness



Society for Neuroscience Abstracts 27(2): 2461



The spontaneous spike discharge of most lumbar (L3) neurons comprising the DSCT (J. Neurosci. 16:1260-1272, 1996) or SRT (Sleep 24:18-25, 2001) is suppressed during active sleep. Neurons in the L3 segment also project to the cerebellum and reticular formation (RF) but are much fewer in number when compared to single projection DSCT or SRT neurons (Soc. Neurosci. Abst., 24:453.9, 1998). In the present study, we investigated whether the spike activity of these dual projection (DP) neurons is reduced during AS. Eight neurons were "backfired" (0.2 ms, <0.6 mA) from the ipsilateral anterior cerebellum and contralateral RF at the level of facial motor nucleus. W and AS were determined using standard criteria (ibid). Mean antidromic latencies determined from the onset of cerebellar and RF stimulus artifacts to spike onset measured 3.64+-0.50 ms (range:2.55-4.70 ms) and 3.10+-0.41 ms (range:2.25-3.90 ms), respectively. For 3 DP neurons, it was estimated that apprx90% of the conduction time for the orthodromically propagated action potentials occurred in the cells' axon prior to its bifurcation (see also Brain Res. Rev., 29:50-82, 1999). The average spontaneous spike rate (+-SE) for 8 neurons to-date during W vs. AS measured 20.02+-0.50 Hz and 23.53+-7.60 Hz, respectively. During AS, there was a 14% increase (n=5) and 25% decrease (n=3) when compared to W. The functional significance of these neurons projecting to diverse supraspinal sites like the cerebellum and RF remains unclear but it appears that DP neurons represent an ascending sensory pathway where opposing modulation may exist during AS.

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