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Altered reproductive endocrine regulation in men with epilepsy: implications for reproductive function and seizures



Altered reproductive endocrine regulation in men with epilepsy: implications for reproductive function and seizures



Annals of Neurology 51(5): 539-542



We studied the impact of cerebral amyloid angiopathy on tissue plasminogen activator-induced cerebral hemorrhages in APP23 transgenic mice. Results show that the intravenous administration of tissue plasminogen activator in APP23 mice leads to an increase in cerebral amyloid angiopathy-associated microhemorrhages and can provoke parenchymal and subarachnoidal hematomas. We conclude that cerebral amyloid angiopathy is a risk factor for cerebral hemorrhage caused by tissue plasminogen activator administration in mice and stress the need for more comprehensive studies of the relation between cerebral amyloid angiopathy and tissue plasminogen activator-induced cerebral hemorrhages in elderly and Alzheimer's disease patients.

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Accession: 034381212

Download citation: RISBibTeXText

PMID: 12112098

DOI: 10.1002/ana.10230



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