+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association of erythropoiesis during autologous blood donation with initial hemoglobin concentration and length of donation period



Association of erythropoiesis during autologous blood donation with initial hemoglobin concentration and length of donation period



Infusionstherapie und Transfusionmedizin 26(6): 353-359



Objective: Assessment of factors that influence erythropoiesis during autologous blood donation. Design: Retrospective study. Setting: Autologous blood donation program at the central laboratory of a teaching hospital. Patients: All consecutive patients with initial hemoglobin concentrations of at least 11.5 g/dl and without acute cardiovascular or infectious diseases who planned to donate autologous blood prior to hip replacement surgery. Interventions: a) Between 1992 and 1997, up to 4 units of 500 ml blood each were withdrawn at weekly intervals within a 21-day period. Starting in January 1996, female patients were offered a more flexible donation scheme extended by 1 week, allowing to omit at least one of the 5 appointments depending on hemoglobin concentrations. b) Iron was substituted by oral (March 1992 to January 1995 and November 1995 to April 1997 2 X 100 mg elemental iron/day) or intravenous routes (January 1995 to June 1995 200 mg elemental iron, April 1995 to September 1995 125 mg elemental iron, September 1995 to November 1995 62.5 mg elemental iron; each dose in an infusion of 500 ml 0.9% NaCl solution after blood donation). c) Based on hemoglobin measurements and body weight, the volumes of donated and regenerated packed red blood cells (RBCs) were calculated for each donor and statistically related to possible factors of influence. Results: In 215 women and 138 men, the mean total volumes of packed RBCs increased by 390 ml and 500 ml, respectively. Higher initial hemoglobin concentrations were significantly associated with the regeneration of greater RBC volumes. Because of a longer donation period, regenerated RBC volumes were higher in 79 women with 5 than in 80 women with 4 appointments (425 +- 173 ml vs. 350 +- 145 ml). In women only, younger age supported a faster RBC regeneration. Associations between erythropoietic regeneration and the form or dose of iron supplementation, reticulocyte counts as well as ferritin and erythropoietin levels were statistically not significant. Conclusions: Initial hemoglobin concentrations and the length of time from withdrawal of the first blood unit till surgery independently correlated with the volume of regenerated RBCs during autologous blood donation. In order to optimize the process of autologous blood donation and facilitate RBC regeneration, a suitable number of blood units should be donated before surgery as early as possible, but a minimum hemoglobin level during the preoperative period must be maintained. Other factors did not significantly correlate with RBC regeneration.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 034451774

Download citation: RISBibTeXText


Related references

Concerning Gesemann M, et al Association of erythropoiesis during autologous blood donation with initial hemoglobin concentration and length of donation period Infusionsther transfusionsmed 1999;26353-359. Infusion Therapy & Transfusion Medicine 27(3): 157, 2000

Umbilical cord blood donation: unrelated donation, familial (directed) donation and autologous donation (private banking). Gynakologisch-Geburtshilfliche Rundschau 43(2): 118-121, 2003

Personal computer-assisted "acceptable hemoglobin concentration". An example of preoperative autologous blood donation. Beitrage Zur Infusionstherapie 26: 220-225, 1990

Erythropoiesis and autologous blood donation. Annals of Hematology 65(Suppl. ): A139, 1992

Autologous blood donation and erythropoiesis. Beitrage Zur Infusionstherapie 30: 272-277, 1992

Short donation intervals in preoperative autologous blood donation in the concept of autologous transfusion. Der Anaesthesist 43(1): 9, 1994

Erythropoiesis and iron metabolism in autologous blood donation. Infusionstherapie und Transfusionsmedizin 19(2): 56-58, 1992

Erythropoiesis and iron metabolism during autologous blood donation. Infusionstherapie 19(2): 56-58, 1992

The present possibilities for routine use of blood-saving measures from the anesthesiologic point of view--theoretical bases and clinical practice. III. Autologous blood donation, autologous donation criteria and organizational measures. Anaesthesiologie und Reanimation 19 Suppl: 18-24, 1994

The variability of compensatory erythropoiesis in repeated autologous blood donation. Transfusion 41(2): 179-183, 2001

Physician recommendation as the key factor in patients' decisions to participate in preoperative autologous blood donation programs: Preoperative Autologous Blood Donation Study Group. American Journal of Surgery 168(1): 2-5, 1994

Product quality in preoperative autologous blood donation--determinants of erythropoiesis. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie 39(9): 566-568, 2004

The correlation between erythropoiesis and thrombopoiesis as an index for pre-operative autologous blood donation. Transfusion Science 21(3): 207-210, 1999

Pre-operative autologous blood donation versus no blood donation in total knee arthroplasty: a prospective randomised trial. International Orthopaedics 38(2): 341-346, 2014

Combined surgical bone donation and autologous blood donation in a community hospital blood bank. Transfusion 27(6): 525, 1987