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Association of estrogen receptor alpha gene polymorphisms with BMD and their affect on estradiol levels in pre- and postmenopausal women in south Indian population from Andhra Pradesh

Jeedigunta, Y.; Bhoomi Reddy, P.Reddy.; Kolla, V.Karunakar.; Munshi, A.; Ananthapur, V.; Narasimulu, G.; Akka, J.

Clinica Chimica Acta; International Journal of Clinical Chemistry 411(7-8): 597-600

2010

ISSN/ISBN: 1873-3492
PMID: 20116372
DOI: 10.1016/j.cca.2010.01.026
Accession: 034451780
Background: Osteoporosis is a multifactorial disorder with a strong genetic component and ESR1 is suggested as a candidate gene for osteoporosis. Therefore the present study is aimed to investigate the role of ESR1 gene polymorphisms and its influence on estradiol levels and BMD in osteoporotic women of Indian ethnicity. Methods: Four-hundred twenty-seven osteoporotic women and 460 age matched controls were included in the study. ESR1 gene polymorphism was assessed by PCR-RFLP method.

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