+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Aversive auditory stimuli activate the human amygdala



Aversive auditory stimuli activate the human amygdala



Society for Neuroscience Abstracts 26(1-2): Abstract No -403 4



Previous neuroimaging studies indicate that the human amygdala activates during exposure to aversive visual, olfactory and gustatory stimuli. In order to examine whether unpleasant auditory stimuli similarly induce activation of the amygdala, we exposed healthy human subjects to aversive sounds while regional cerebral blood flow (rCBF) was assayed with O-15 PET. Six subjects, all of whom described themselves as reactive to unpleasant sounds, participated in the study. The aversive sound condition consisted of a collage of environmental sounds (e.g., nails scratching, metal scraping, Styrofoam squeaking, a dentist drill) presented in headphones at a non-painful volume. Subjects consistently described the sounds as extremely aversive. White noise served as a control condition. rCBF was estimated with an ECAT 953B camera in 3D mode, with a 60-s scan acquisition. Relative to white noise, the aversive sounds produced significant rCBF increases in the lateral amygdala/claustrum region, the dorsal brainstem, ventral striatum, putamen and right auditory association cortices. These data indicate that the human amygdala activates in response to aversive auditory stimuli. Taken together with previous studies, this finding suggests that the human amygdala plays a similar role in evaluating and directing responses to aversive stimuli across multiple sensory modalities.

(PDF emailed within 1 workday: $29.90)

Accession: 034463885

Download citation: RISBibTeXText


Related references

Deviant auditory stimuli activate human left and right auditory cortex differently. Cerebral Cortex 6(2): 288-296, 1996

Do auditory stimuli activate human parietal brain regions?. Neuroreport 6(13): 1712-1714, 1995

Updating fearful memories with extinction training during reconsolidation: a human study using auditory aversive stimuli. Plos One 7(6): E38849, 2012

Amplitude and frequency-modulated stimuli activate common regions of human auditory cortex. Cerebral Cortex 13(7): 773-781, 2003

The lateral amygdala processes the value of conditioned and unconditioned aversive stimuli. Neuroscience 133(2): 561-569, 2005

Role of amygdala in conditioned versus unconditioned responding to aversive stimuli. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 85 11, 2002

Amygdala c-Fos induction corresponds to unconditioned and conditioned aversive stimuli but not to freezing. Behavioural Brain Research 152(1): 109-120, 2004

Amygdala activity related to enhanced memory for pleasant and aversive stimuli. Nature Neuroscience 2(3): 289-293, 1999

Anticipation of aversive stimuli activates extended amygdala in unipolar depression. Journal of Psychiatric Research 41(6): 511-522, 2006

Emotion, olfaction, and the human amygdala: Amygdala activation during aversive olfactory stimulation. Proceedings of the National Academy of Sciences of the United States of America 94(8): 4119-4124, 1997

Catechol-O-methyltransferase gene variation: impact on amygdala response to aversive stimuli. Neuroimage 60(4): 2222-2229, 2012

The fear arousing and motivational properties of aversive stimuli are mediated by different systems within the amygdala. Society for Neuroscience Abstracts 24(1-2): 1684, 1998

Expectation modulates neural responses to pleasant and aversive stimuli in primate amygdala. Neuron 55(6): 970-984, 2007

Role of the medial amygdala in mediating responses to aversive stimuli leading to hypertension. Clinical and Experimental Pharmacology and Physiology 38(2): 136-143, 2011

Aversive properties of auditory stimuli. Learning & Motivation. 26(2): 101-115, 1995