Azole derivative with leukotriene antagonizing activity and thromboxane A2 antagonizing activity
Nagaoka, N.; Yokota, M.; Akane, H.; Arakida, Y.; Isomura, Y.
Official Gazette of the United States Patent and Trademark Office Patents 1228(2)
An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and being useful in preventing or treating allergic diseases, ischemic heart diseases or ischemic brain diseases, and a medicinal composition containing the same as the active ingredient, wherein R1 and R2 may be the same or different and represent each hydrogen, cycloalkyl, etc., or R1 and R2 together with (a) may form a fused ring (b) or (c) which may be substituted by optionally substituted lower alkyl, amino, etc.; R3, R6, R7, R8 may be the same or different and represent each hydrogen, amino, etc.; R4 represents cyano, tetrazolyl, --COOR9, etc.; R5 represents hydrogen or lower alkyl; D represents optionally substituted lower alkylene; X and Z may be the same or different and represent each oxygen or sulfur; Y represents --Ndbd or --CHdbd; A represents --O--B--, --B--O--, --S--B--, --B--S-- or --B-- (B being lower alkylene or lower alkenylene); and n is 0, 1, or 2.