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Beneficial influence of restraint stress on caerulein induced pancreatitis in rats role of endogenous glucocorticoids


Beneficial influence of restraint stress on caerulein induced pancreatitis in rats role of endogenous glucocorticoids



Digestive Disease Week Abstracts and Itinerary Planner: Abstract No. S1793



DOI: 10.1016/s0016-5085(03)81344-6

Stress is reportedly known to exert a protective effect against caerulein-induced pancreatitis. Although HSP60 has been proposed as a possible mechanism of the stress-induced protection, the relation of other factors to this protection remains to be explored. In the present study, we examined the influence of restraint stress on caerulein-induced pancreatitis in rats and investigated the role of endogenous glucocorticoids evoked by restraint stress in this action. Method: Pancreatitis was induced in male Wistar rats by caerulein given SC 4 times every hour. Restraint stress was performed by immobilizing the animals in Bollman cages from 30 min before the first injection of caerulein. Serum amylase level, pancreas weight, tissue MPO activity, as well as histological findings were evaluated 6 h after the first caerulein injection. Expression of HSP60 was also examined in the pancreas by Western blot after 3 h-stress. Results: Caerulein injections produced marked increases in serum amylase levels, accompanied by tissue edema and increases in pancreas weight as well as MPO activity. Restraint stress significantly reduced the increase in serum amylase levels but not pancreas weight and MPO activity, the effect being totally antagonized by pretreatment with mifepristone, a glucocorticoid receptor antagonist. On the other hand, dexamethasone dose-dependently prevented the increases in the amylase level and pancreas weight in response to caerulein. Histologically, restraint stress apparently suppressed the intra-lobular edema induced by caerulein, while dexamethasone markedly reduced the tissue edema as well as inflammatory cell infiltration. The expression of HSP60 in the pancreas was not affected by restraint stress. Conclusions: These results suggest that restraint stress exerts a beneficial effect on caerulein-induced pancreatitis, probably mediated by endogenous glucocorticoids. Since dexamethasone also exhibits beneficial effects on the pancreatitis, it is assumed that short-term administration of glucocorticoids has a potential of clinical application for treatment of pancreatitis.

Accession: 034476072

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