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Beta-conglycinin deficient in isoflavones and saponins did not lower plasma concentrations of lipoproteins and cholesterol over time in moderately hypercholesterolemic women



Beta-conglycinin deficient in isoflavones and saponins did not lower plasma concentrations of lipoproteins and cholesterol over time in moderately hypercholesterolemic women



FASEB Journal 15(4): A274, March 7



Dietary soy protein apparently reduces plasma cholesterol concentrations in hypercholesterolemic individuals, but it is uncertain which components associated with soy protein are responsible for its hypocholesterolemic effect. Fifty-two women with low-density lipoprotein (LDL) cholesterol levels between 2.58 mmol/L and 5.17 mmol/L were randomly assigned to one of three groups for 28 days. Subjects received one muffin per day, of the following composition depending on assigned treatment: 1) 28 g of casein as the protein source; 2) 28g of beta-conglycinin, a major soy protein, containing 4 mumol of isoflavones and 2 mumol of saponins; 3) 28 g of beta-conglycinin containing 44 mumol of isoflavones and 58 mumol of saponins. After 28 days of feeding, groups fed beta-conglycinin containing low or high levels of isoflavones and saponins had similar total plasma cholesterol or LDL cholesterol compared with the group fed casein. At days 14 and 28, women fed beta-conglycinin containing high levels of isoflavones and saponins had significantly lower total plasma cholesterol and LDL cholesterol concentrations compared with day 0. In women fed casein, LDL cholesterol concentration was significantly decreased at day 28 compared with day 0. Thus the components associated with beta-conglycinin, including isoflavones and saponins, caused more rapid cholesterol lowering than observed with the casein control group. The P: S ratio (1.5:1), as determined by food recalls during the treatment period in this study, may have masked a small effect of beta-conglycinin containing high levels of isoflavones and saponins to lower total plasma cholesterol and LDL cholesterol levels. beta-conglycinin low in isoflavones and saponins was ineffective at lowering plasma cholesterol over 14 or 28 days.

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Accession: 034478987

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