+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Can age of patients, enuresis severity and positive family history be predictors of success with desmopressin treatment in primary nocturnal enuresis?



Can age of patients, enuresis severity and positive family history be predictors of success with desmopressin treatment in primary nocturnal enuresis?



Cocuk Sagligi ve Hastaliklari Dergisi 47(1): 17-22



We evaluated in this study the factors that affect the outcome of oral desmopressin (DDAVP) in patients who relapse after treatment. Between January 2000 and August 2001, 71 boys and 52 girls underwent DDAVP treatment for monosymptomatic nocturnal enuresis. All patients were administered 0.2 mg DDAVP/daily treatment (one hour before sleeping). Patients were called to evaluate the enuresis after an initial two week dose titration, and the non-responders were increased to 0.4 mg/daily treatment for three months. Those who did not respond to 0.4 mg desmopressin were excluded from the study. Three months later DDAVP treatment was stopped and the patients were called follow-up. Those still with enuresis after three months of treatment were evaluated for effect of age of patients, enuresis severity and positive family history. The mean follow-up DDAVP therapy was 9.2 (6-18) months. After cessation of the drug, 21 of 45 patients (46.6%) who responded to 0.2 mg of DDAVP and 13 of 24 patients (54%) who responded to 0.4 mg of DDAVP were relapsed. Age, enuresis severity and positive family history were not related to outcome of DDAVP treatment (p>0.05). Age of patients, enuresis severity and positive family history were not significant in order to estimate outcome of treatment with DDAVP.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 034523908

Download citation: RISBibTeXText


Related references

Efficacy of an enuresis alarm, desmopressin, and combination therapy in the treatment of saudi children with primary monosymptomatic nocturnal enuresis. Korean Journal of Urology 54(11): 783-790, 2013

Efficacy and safety during long-term treatment of primary monosymptomatic nocturnal enuresis with desmopressin. Swedish Enuresis Trial Group. Acta Paediatrica 88(11): 1274-1278, 1999

Efficacy of desmopressin and enuresis alarm as first and second line treatment for primary monosymptomatic nocturnal enuresis: prospective randomized crossover study. Journal of Urology 184(6): 2521-2526, 2010

Long-term treatment with desmopressin in children with primary monosymptomatic nocturnal enuresis: an open multicentre study. Swedish Enuresis Trial (SWEET) Group. British Journal of Urology 82(5): 704-709, 1998

Combined therapy of enuresis alarm and desmopressin in the treatment of nocturnal enuresis. European Journal of Pediatrics 148(5): 465-467, 1989

Combination of the enuresis alarm and desmopressin: second line treatment for nocturnal enuresis. Journal of Urology 179(3): 1128-1131, 2008

Combined treatment with enuresis alarm and desmopressin for nocturnal enuresis. Acta Paediatrica 84(9): 1014-1018, 1995

Total Genome Scan Analysis in a Single Extended Family for Primary Nocturnal Enuresis: Evidence for a NewLocus (ENUR3) for Primary Nocturnal Enuresis on Chromosome 22q11. European Urology 33(Suppl. 3): 34-36, 1998

Total genome scan analysis in a single extended family for primary nocturnal enuresis: evidence for a new locus (ENUR3) for primary nocturnal enuresis on chromosome 22q11. European Urology 33 Suppl 3: 34-36, 1998

Desmopressin alone versus desmopressin and an anticholinergic in the first-line treatment of primary monosymptomatic nocturnal enuresis: a multicenter study. Pediatric Nephrology 29(7): 1195-1200, 2015

The role of family history in predicting response to desmopressin in nocturnal enuresis. Journal of Urology 150(2 Pt 1): 444-445, 1993

Comparison of effects of treatment of primary nocturnal enuresis with oxybutynin plus desmopressin, desmopressin alone or imipramine alone: a randomized controlled clinical trial. Journal of Urology 174(3): 1084-1087, 2005

Comparison of Effects of Treatment of Primary Nocturnal Enuresis With Oxybutynin Plus Desmopressin, Desmopressin Alone or Imipramine Alone: A Randomized Controlled Clinical Trial. Yearbook of Urology 2006: 259-260, 2006

Comparison of combined treatment with desmopressin plus oxybutynin and desmopressin plus tolterodine in treatment of children with primary nocturnal enuresis. Journal of Renal Injury Prevention 4(3): 80-86, 2015

Desmopressin: the treatment of primary nocturnal enuresis. Archivos Espanoles de Urologia 48(3): 278-281, 1995