+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Chronic hemolytic anemia associated with glucose 6-phosphate dehydrogenase 1159 C fwdarw T deficiency associated with Gilbert syndrome in a Turkish patient



Chronic hemolytic anemia associated with glucose 6-phosphate dehydrogenase 1159 C fwdarw T deficiency associated with Gilbert syndrome in a Turkish patient



Pediatric Hematology & Oncology 19(1): 39-44, January-February



The case of an 8-year-old male child with severe kernicterus sequelae is presented in this paper. The child's hemoglobin value varied between 6.0 and 10.8 g/dL and his reticulocyte count ranged between 3.4 and 46.0% during the steady-state condition and hyperhemolytic crisis, respectively. A chronic hemolytic type of red cell G6PD deficiency was diagnosed. DNA studies indicate that the mutation was G6PD Guadalajara 1159 C fwdarw T (387 Arg fwdarw Cys) that is situated at the NADP binding site. Additionally, extra nucleotides of (TA) in the A(TA)n TAA motif of the promoter region of the uridine diphosphate-glucuronosyltransferase gene (UGT-1 A) were found to be homozygous in the patient. The coexistence of Gilbert syndrome with a chronic type of G6PD deficiency was suggested as a cause of neonatal hyperbilirubinemia leading to kernicterus.

(PDF emailed within 1 workday: $29.90)

Accession: 034578946

Download citation: RISBibTeXText


Related references

Chronic hemolytic anemia associated with glucose 6-phosphate dehydrogenase (Guadalajara)1 159 C --> T (387 Arg --> Cys) deficiency associated with Gilbert syndrome in a Turkish patient. Pediatric Hematology and Oncology 19(1): 39-44, 2002

Laparoscopic cholecystectomy and postoperative pain control in a patient with chronic non-spherocytic hemolytic anemia from glucose-6-phosphate dehydrogenase deficiency. Journal of Clinical Anesthesia 54: 128-129, 2018

A new glucose 6 phosphate dehydrogenase variant in a patient with chronic nonspherocytic hemolytic anemia glucose 6 phosphate dehydrogenase maebashi. Acta Haematologica Japonica 44(6): 1097-1101, 1981

Chronic Hemolytic Anemia with Glucose-6-Phosphate Dehydrogenase Deficiency. Bulletins et Memoires de la Societe Medicale des Hopitaux de Paris 115: 467-474, 1964

Hemolytic anemia by glucose 6 phosphate dehydrogenase deficiency in an elderly patient. Semaine des Hopitaux 65(30): 1863, 1989

Metformin-induced hemolytic anemia in a patient with glucose-6- phosphate dehydrogenase deficiency. Diabetes Care 26(3): 956-957, 2003

Hemolytic anemia after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. American Journal of Medicine 110(3): 240-241, February 15, 2001

Metformin-Induced Hemolytic Anemia in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency. American Journal of Therapeutics 23(2): E575-E578, 2016

Chronic hemolytic anemia due to glucose-6-phosphate dehydrogenase deficiency or glutathione synthetase deficiency: the role of vitamin E in its treatment. Annals of the New York Academy of Sciences 393: 348-360, 1982

Chronic hemolytic anemia due to erythrocytic deficiency of glucose-60-phosphate dehydrogenase (G6PD). La Pediatria 87(3): V-Vi, 1979

Autoimmune hemolytic anemia in a patient with a deficiency of red cell glucose-6-phosphate dehydrogenase activity. Johns Hopkins Medical Journal 126(3): 139-145, 1970

Chronic hemolytic anemia due to glucose-6-phosphate dehydrogenase deficiency or glutathione symthetase deficiency: the role of vitamin E in its treatment Alpha tocopherol. Annals of the New York Academy of Sciences93(393): 348-360, 1982

Chronic hemolytic anemia due to glucose 6 phosphate dehydrogenase ec 1.1.1.49 deficiency or glutathione synthetase ec 6.3.2.3 deficiency the role of vitamin e in its treatment. Lubin, B And L J Machlin (Ed ) Annals Of The New York Academy Of Sciences, Vol 393 Vitamin E: Biochemical, Hematological And Clinical Aspects; Meeting, New York, N Y , Usa, Nov 11-13, 1981 Xi+506p The New York Academy Of Sciences: New York, N Y , Usa Illus Paper P348-360, 1982

II. Chronic hemolytic anemia caused by erythrocytic deficiency of glucose-6-phosphate dehydrogenase (G6PD). La Pediatria 87(4): V-Vi, 1979

Aortic valve replacement for a patient with glucose-6-phosphate dehydrogenase deficiency and autoimmune hemolytic anemia. Journal of Cardiac Surgery 20(4): 380-381, 2005