+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Coagulation-associated enhancement of fibrinolytic activity via a neutralization of PAI-1 activity



Coagulation-associated enhancement of fibrinolytic activity via a neutralization of PAI-1 activity



Seminars in Thrombosis and Hemostasis 26(1): 39-42



Total fibrinolytic activity in the vasculature is finely tuned by the balance between tissue plasminogen activator and plasminogen activator inhibitor type 1 (PAI-1). Although PAI-1 targets plasminogen activators, it also reacts with other serine proteases such as thrombin and factor Xa. The latter was shown to interact with PAI-1 only when a physiological concentration of calcium ions (Ca++) is present. Through such interaction, thrombin and Ca++-bound factor Xa shortened fibrin clot lysis times in a purified system by neutralizing PAI-1 activity. Both unfractionated heparin and vitronectin were shown to enhance the clot lysis further. Together with the cleavage and inactivation of PAI-1 by human neutrophil elastase, which was reported previously from our laboratory, such neutralization of PAI-1 activity by these serine proteases was shown to be strongly involved in the coagulation-associated enhancement of fibrinolytic activity.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 034599110

Download citation: RISBibTeXText

PMID: 10805280


Related references

A simple quantitative assay of 125I-labeled alpha-bungarotoxin binding to soluble and membrane-bound acetylcholine receptor protein. Analytical Biochemistry 80(2): 531-539, 1977

Studies on the coagulation and fibrinolytic activity of the human aorta. I. Vasculokinase like substance in the aorta. Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 58(7): 605-612, 1969

Coagulation and fibrinolytic activity of cerebrospinal fluid. Journal of Clinical Pathology 31(5): 488-492, 1978

Coagulation and fibrinolytic activity in behcet's disease. Thrombosis and Haemostasis 66(3): 292-294, 1991

"Studies on serum amylases in ovarian, prostatic and colonic cancer". Indian Journal of Cancer 19(4): 204-208, 1982

Blood coagulation, fibrinolysis and woundhealing. Medizinische Novitaten 42: 1972-1979, 1959

Effects of dilazep on coronary and systemic hemodynamics in humans. American Heart Journal 108(2): 276-285, 1984

Platelet factor 4 gene expression in a human megakaryocytic leukemia cell line cmk and its differentiated subclone cmk11 5. Experimental Hematology (Charlottesville) 19(9): 923-927, 1991

Neutralization of the neurotoxin of E. coli. Part 2. Determination of the strength of anti-neurotoxic coli-serum. Zentralblatt für Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 22(6): 499-509, 1975

Changes of coagulation and fibrinolysis in blood of rats with intestinal obstruction associated with strangulation. Gastroenterology 112(4 Suppl. ): A1461, 1997

Enhancement of fibrinolysis by venous occlusion. Results of long-term thrombelastography and activator determination. Thrombosis et Diathesis Haemorrhagica 21(2): 304-310, 1969

Coagulation and fibrinolytic activity of blood from the corpus cavernosum. Archivio Italiano di Urologia Nefrologia Andrologia 63(4): 471-473, 1991

Changes in coagulation and fibrinolysis system in lung infection. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15(3): 180-181, 2003

Changes of coagulation and fibrinolytic activity during microgravity. Japanese Journal of Physiology 39(Suppl.): S236, 1989

Coagulation and fibrinolysis in rats poisoned with mercuric chloride. Polish Journal of Pharmacology and Pharmacy 40(4): 365-371, 1988