Comparative in vitro antimicrobial activities of the newly synthesized quinolone HSR-903, sitafloxacin , gatifloxacin , and levofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex

Tomioka, H.; Sato, K.; Akaki, T.; Kajitani, H.; Kawahara, S.; Sakatani, M.

Antimicrobial Agents and Chemotherapy 43(12): 3001-3004

1999


ISSN/ISBN: 0066-4804
Accession: 034613245

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Abstract
We compared the in vitro antimycobacterial activity of a new fluoroquinolone, HSR-903, with strong activity against gram-positive cocci with those of levofloxacin (LVFX), sitafloxacin (STFX), and gatifloxacin (GFLX). The MICs of the quinolones for Mycobacterium tuberculosis and Mycobacterium avium complex were in the order STFX apprxeq GFLX < LVFX ltoreq HSR-903 and STFX ltoreq GFLX ltoreq HSR-903 ltoreq LVFX, respectively. HSR-903 effectively eliminated intramacrophagial M. tuberculosis, as did LVFX, and exhibited bacteriostatic effects against M. tuberculosis replicating in type H alveolar cells.