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Comparing Arterial Oxygen Saturation from a Nellcor Oxygen Saturation Monitor, IL Co-Oximeter and with Varying Concentrations of Hemoglobin-Based Oxygen Carrier in a Dog Hemorrhage Model



Comparing Arterial Oxygen Saturation from a Nellcor Oxygen Saturation Monitor, IL Co-Oximeter and with Varying Concentrations of Hemoglobin-Based Oxygen Carrier in a Dog Hemorrhage Model



Anesthesiology Abstracts of Scientific Papers Annual Meeting (2001): Abstract No. A-557



INTRODUCTION: Different hemoglobins, including hemoglobin-based oxygen carriers (HBOC) have been documented to alter SaO2 measurements (1). We compared SaO2 values from oxygen saturation monitor and co-oximeter with calculated values from oxygen content (2). METHODS: In 17 anesthetized, splenectomized mixed breed dogs of both genders, the femoral artery was canulated (3). Blood samples were anaerobically collected at four time points: baseline, one hour after completion of 30-minute hemorrhage (about 40% of circulating blood volume, to keep mean arterial blood pressure at 50 mm Hg, immediately, and then 3 hours after resuscitation, using either 30 ml/kg 6% hetastarch (Hextend(R), Abbott Laboratories, Chicago, IL), or 10, or 20 ml/kg Hemoglobin Glutamer-200 (Bovine) (Oxyglobin(R), Biopure, Cambridge, MA) with 20 or 10 ml/kg 6% hetastarch respectively. Samples were immediately evaluated on Model 482 Co-Oximeter(R) (Instrumentation Laboratories, Lexington, MA) in duplicates and averaged. The oxygen saturation was recorded from the tongue with a Nellcor reusable finger probe and N-200 Pulse Oximeter (Nellcor, Inc, Hayward, CA). Based on the measurements obtained with the investigated instruments (including hemoglobin (Hb) using the HemoCue(R),(Angelholm, Sweden,4), oxygen content (Co2) was calculated for each sample using the following equation: Co2 = (SO2) x (1.32 bHb + 1.39cHb) +pO2 x 0.003, where: SO2 - hemoglobin oxygen saturation, bHb - bovine hemoglobin concentration, cHb - canine hemoglobin concentration. The constants 1.32 and 1.39 represent the theoretical oxygen capacities of 1 g of bovine and canine hemoglobin calculated by molecular weight (68,000 and 64,458 Dalton, respectively). Results were compared with the oxygen content from the LEX02CON-K (Hospex Fiberoptics, Chestnut Hill, MA). Statistical analysis was performed using SPSS 10.1 software with significance level set at 0.05. RESULTS: Calculated values were in the 10% difference range compared to measured. The results were almost identical in all groups and there was no significant correlation between the concentration of HBOC and the difference in values between the methods. The overall correlation between two methods was statistically significant (r = 0.87, p<0.05). CONCLUSION:The Nellcor oxygen saturation monitor, and IL co-oximeter are accurate analyzers for measurement of arterial oxygen saturation after 6% Hetastarch or a bovine HBOC/6% Hetastarch infusion in the canine model.

Accession: 034615236

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